Table 1 PTMs of mAb-1E10 detected by mass spectrometry.
From: Physicochemical and biological characterization of 1E10 Anti-Idiotype vaccine
Modifications | 1E10 AF | 1E10 ST |
|---|---|---|
N-term glutamine to pyroglutamic acid | + | + |
Glycosylation of Asn294 | + | + |
Deamidation of Asn141 (heavy chain) | + | + |
Deamidation of Asn157 (light chain) | + | + |
Deamidation of Asn161 (light chain) | + | + |
Oxidation of M396 | + | - |