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  1. Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the ...

    Authors: Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed and Sahel Rahimi
    Citation: BMC Biotechnology 2021 21:51
    Content type: Research Published on:

  2. Nattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase nattokinase yields, fermentation conditions, strains, cultivation media, a...

    Authors: Yan Guangbo, Shu Min, Shen Wei, Ma Lixin, Zhai Chao, Wang Yaping and Huang Zunxi
    Citation: BMC Biotechnology 2021 21:49
    Content type: Research Published on:

  3. Extracellular microRNAs (miRNAs), released from cells into biofluids, have emerged as promising biomarkers for diagnostic and prognostic purposes. Several RNA isolation methods are available for the analysis o...

    Authors: Henk P. Roest, Jan N. M. IJzermans and Luc J. W. van der Laan
    Citation: BMC Biotechnology 2021 21:48
    Content type: Research article Published on:

  4. Although laccase has a good catalytic oxidation ability, free laccase shows a poor stability. Enzyme immobilization is a common method to improve enzyme stability and endow the enzyme with reusability. Adsorpt...

    Authors: Zhaobo Wang, Dajun Ren, Shan Jiang, Hongyan Yu, Yaohui Cheng, Shuqin Zhang, Xiaoqing Zhang and Wangsheng Chen
    Citation: BMC Biotechnology 2021 21:47
    Content type: Research Published on:

  7. 4-vinylphenols produced by phenolic acid degradation catalyzed by phenolic acid decarboxylase can be used in food additives as well as flavor and fragrance industry. Improving the catalytic characters of pheno...

    Authors: Qin Li, Ying Xia, Ting Zhao, Yuanyuan Gong, Shangling Fang and Maobin Chen
    Citation: BMC Biotechnology 2021 21:44
    Content type: Research Published on:

  8. The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yi...

    Authors: Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes and Paula Meleady
    Citation: BMC Biotechnology 2021 21:43
    Content type: Research Published on:

  9. Protein C receptor (Procr) has recently been shown to mark resident adult stem cells in the mammary gland, vascular system, and pancreatic islets. More so, high Procr expression was also detected and used as i...

    Authors: Ting Wu, Yinghua Wang, Tianxiong Xiao, Yirui Ai, Jinsong Li, Yi Arial Zeng and Qing Cissy Yu
    Citation: BMC Biotechnology 2021 21:42
    Content type: Research Published on:

  10. CCR6 chemokine receptor is an important target in inflammatory diseases. Th17 cells express CCR6 and a number of inflammatory cytokines, including IL-17 and IL-22, which are involved in the propagation of infl...

    Authors: Sara Gómez-Melero, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Isaac Túnez-Fiñana and Elier Paz-Rojas
    Citation: BMC Biotechnology 2021 21:41
    Content type: Research Published on:

  11. Most commercial phycocyanins are extracted from a filamentous cyanobacterium, Arthrospira (Spirulina) platensis. Owing to the expenses of culture and complexities of the physical and chemical methods of phycocyan...

    Authors: Jinichi Aoki, Daisaku Sasaki and Munehiko Asayama
    Citation: BMC Biotechnology 2021 21:40
    Content type: Research Published on:

  12. HSPB5 is an ATP-independent molecular chaperone that is induced by heat shock or other proteotoxic stresses. HSPB5 is cytoprotective against stress both intracellularly and extracellularly. It acts as a potent...

    Authors: Jing Li, Jingjing Yu, Wenxian Xue, Huili Huang, Longjun Yan, Fan Sang, Shuangshuang An, Jing Zhang, Mingli Wang, Jun Zhang, Hui Li, Xiukun Cui, Jiang He and Yanzhong Hu
    Citation: BMC Biotechnology 2021 21:39
    Content type: Research Published on:

  13. Neuroinflammation has been identified to be the key player in most neurodegenerative diseases. If neuroinflammation is left to be unresolved, chronic neuroinflammation will be establish. Such situation is due ...

    Authors: M. A. F. Yahaya, A. R. Abu Bakar, J. Stanslas, N. Nordin, M. Zainol and M. Z. Mehat
    Citation: BMC Biotechnology 2021 21:38
    Content type: Research Published on:

  14. Laccases (EC 1.10.3.2) are multi-copper oxidoreductases with great biotechnological importance due to their high oxidative potential and utility for removing synthetic dyes, oxidizing phenolic compounds, and d...

    Authors: Leidy D. Ardila-Leal, Pedro A. Monterey-Gutiérrez, Raúl A. Poutou-Piñales, Balkys E. Quevedo-Hidalgo, Johan F. Galindo and Aura M. Pedroza-Rodríguez
    Citation: BMC Biotechnology 2021 21:37
    Content type: Research Published on:

  15. DNA testing in the cattle industry undergoes multiple hurdles. Successful genotyping involves the transportation of samples from the field to the laboratory in a chilled environment followed by DNA extraction,...

    Authors: R. R. Alyethodi, U. Singh, S. Kumar, R. Alex, G. S. Sengar, T. V. Raja, R. Deb and B. Prakash
    Citation: BMC Biotechnology 2021 21:36
    Content type: Methodology article Published on:

  16. The purpose of this study was to develop a reliable DNA extraction protocol to use on individual Teladorsagia circumcincta nematode specimens to produce high quality DNA for genome sequencing and phylogenetic ana...

    Authors: S. Sloan, C. J. Jenvey, D. Piedrafita, S. Preston and M. J. Stear
    Citation: BMC Biotechnology 2021 21:35
    Content type: Research article Published on:

  17. Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria. Antibiotic therapy and the use of diphtheria antitoxin is a...

    Authors: Morteza Rezaeifard, Roya Solhi, Mohammad Mohammadi, Ebrahim Abbasi and Mahdi Aminian
    Citation: BMC Biotechnology 2021 21:34
    Content type: Research article Published on:

  18. Amylases produced by fungi during solid-state fermentation are the most widely used commercial enzymes to meet the ever-increasing demands of the global enzyme market. The use of low-cost substrates to curtail...

    Authors: M. Balakrishnan, G. Jeevarathinam, S. Kiran Santhosh Kumar, Iniyakumar Muniraj and Sivakumar Uthandi
    Citation: BMC Biotechnology 2021 21:33
    Content type: Research article Published on:

  20. Microorganisms, including Bacillus species are used to help control plant pathogens, thereby reducing reliance on synthetic pesticides in agriculture. Bacillus velezensis strain 1B-23 has been shown to reduce sym...

    Authors: Michelle S. M. Li, David A. Piccoli, Tim McDowell, Jacqueline MacDonald, Justin Renaud and Ze-Chun Yuan
    Citation: BMC Biotechnology 2021 21:31
    Content type: Research Published on:

  21. Bovine viral diarrhea virus (BVDV) is a major economic disease that has been spread in most countries. In addition to vaccination, one of the main ways to control the disease and prevent it from spreading is t...

    Authors: Zahra Heidari, Seyedeh Elham Rezatofighi and Saadat Rastegarzadeh
    Citation: BMC Biotechnology 2021 21:30
    Content type: Research article Published on:

  22. Quantitative analysis of differential gene expression is of central importance in molecular life sciences. The Gene eXpression Profiling technology (GeXP) relies on multiplex RT-PCR and subsequent capillary el...

    Authors: Pauline Marquardt, Britta Werthmann, Viktoria Rätzel, Markus Haas and Wolfgang Marwan
    Citation: BMC Biotechnology 2021 21:29
    Content type: Methodology article Published on:

  23. Microbial polysaccharides have been reported to possess remarkable bioactivities. Physarum polycephalum is a species of slime mold for which the microplasmodia are capable of rapid growth and can produce a signif...

    Authors: Tuyen T. H. Do, Tran N. B. Lai, Steven L. Stephenson and Hanh T. M. Tran
    Citation: BMC Biotechnology 2021 21:28
    Content type: Research article Published on:

  24. Phakopsora pachyrhizi is a biotrophic fungal pathogen responsible for the Asian soybean rust disease causing important yield losses in tropical and subtropical soybean-producing countries. P. pachyrhizi triggers ...

    Authors: L. Cabre, S. Peyrard, C. Sirven, L. Gilles, B. Pelissier, S. Ducerf and N. Poussereau
    Citation: BMC Biotechnology 2021 21:27
    Content type: Research article Published on:

  25. The production of agricultural wastes still growing as a consequence of the population growing. However, the majority of these residues are under-utilized due their chemical composition, which is mainly compos...

    Authors: Martha María Arevalos-Sánchez, Adrián Omar Maynez-Perez, Felipe A. Rodríguez-Almeida, José Alfredo Martínez-Quintana, Fidel Alejandro Sanchez-Flores, Monserrath Felix-Portillo, América Chavéz-Martínez, Myrna Elena Olvera-García, Oscar Ruiz-Barrera and Agustín Corral-Luna
    Citation: BMC Biotechnology 2021 21:26
    Content type: Research article Published on:

  28. Ogataea polymorpha is a thermotolerant, methylotrophic yeast with significant industrial applications. While previously mainly used for protein synthesis, it also holds promise for producing platform chemicals. O...

    Authors: Ulf W Liebal, Brigida A Fabry, Aarthi Ravikrishnan, Constantin VL Schedel, Simone Schmitz, Lars M Blank and Birgitta E Ebert
    Citation: BMC Biotechnology 2021 21:23
    Content type: Research article Published on:

  29. The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly spread worldwide. Researchers are trying to find a way to treat this disease as soon as possible. The present study aimed to identify t...

    Authors: Masoumeh Adhami, Balal Sadeghi, Ali Rezapour, Ali Akbar Haghdoost and Habib MotieGhader
    Citation: BMC Biotechnology 2021 21:22
    Content type: Research article Published on:

  30. Proteases are important for hydrolysis of proteins to generate peptides with many bioactivities. Thus, the development of novel proteases with high activities is meaningful to discover bioactive peptides. Beca...

    Authors: Chang Chang, Siyi Gong, Zhiping Liu, Qiaojuan Yan and Zhengqiang Jiang
    Citation: BMC Biotechnology 2021 21:21
    Content type: Research article Published on:

  31. Over the past decade, therapeutic messenger RNAs (mRNAs) have emerged as a highly promising new class of drugs for protein replacement therapies. Due to the recent developments, the incorporation of modified n...

    Authors: Cynthia Aslan, Seyed Hossein Kiaie, Naime Majidi Zolbanin, Parisa Lotfinejad, Reihaneh Ramezani, Fatah Kashanchi and Reza Jafari
    Citation: BMC Biotechnology 2021 21:20
    Content type: Review Published on:

  33. Aldehyde dehydrogenases are vital for aerobic hydrocarbon degradation and is involved in the last step of catalysing the oxidation of aldehydes to carboxylic acids. With the global increase in hydrocarbon poll...

    Authors: Cindy Baburam and Naser Aliye Feto
    Citation: BMC Biotechnology 2021 21:18
    Content type: Research article Published on:

  34. Alanine decarboxylase (AlaDC), specifically present in tea plants, is crucial for theanine biosynthesis. Serine decarboxylase (SDC), found in many plants, is a protein most closely related to AlaDC. To investi...

    Authors: Peixian Bai, Liyuan Wang, Kang Wei, Li Ruan, Liyun Wu, Mengdi He, Dejiang Ni and Hao Cheng
    Citation: BMC Biotechnology 2021 21:17
    Content type: Research article Published on:

  35. A plant growth-promoting endophytic bacterium PVL1 isolated from the leaf of Vanda cristata has the ability to colonize with roots of plants and protect the plant. PVL1 was isolated using laboratory synthetic ...

    Authors: Sujit Shah, Krishna Chand, Bhagwan Rekadwad, Yogesh S. Shouche, Jyotsna Sharma and Bijaya Pant
    Citation: BMC Biotechnology 2021 21:16
    Content type: Research article Published on:

  36. CRISPR-Cas genome editing technologies have revolutionized biotechnological research particularly in functional genomics and synthetic biology. As an alternative to the most studied and well-developed CRISPR/C...

    Authors: Dede Abdulrachman, Lily Eurwilaichitr, Verawat Champreda, Duriya Chantasingh and Kusol Pootanakit
    Citation: BMC Biotechnology 2021 21:15
    Content type: Research article Published on:

  37. Levan is a well-known homopolymer of fructose composed predominantly of β-(2, 6) fructofuranosyl linkages in the backbone with occasional β-(2, 1) linkages in the branch chains with varied applications. Howeve...

    Authors: Jin Han, Huafeng Feng, Xiaohua Wang, Zhenmin Liu and Zhengjun Wu
    Citation: BMC Biotechnology 2021 21:14
    Content type: Research article Published on:

  39. Lyso-phosphatidylethanolamine (LPE) is a natural phospholipid that functions in the early stages of plant senescence. Plant innate immunity and early leaf senescence share molecular components. To reveal conserve...

    Authors: Ronny Völz, Ju-Young Park, William Harris, Sungkee Hwang and Yong-Hwan Lee
    Citation: BMC Biotechnology 2021 21:12
    Content type: Research article Published on:

  40. Human epithelial cell sheets (ECSs) are used to clinically treat epithelial conditions such as burns, corneal blindness, middle ear cholesteatoma and vitiligo. As a widely used material in clinic, there is lit...

    Authors: Dongliang Zhang, Jialiang Shao, Jingming Zhuang, Shukui Zhou, Shuo Yin, Fuyue Wu, Jiangang Hou and Xiang Wang
    Citation: BMC Biotechnology 2021 21:11
    Content type: Research article Published on:

  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee
    Citation: BMC Biotechnology 2021 21:10
    Content type: Correction Published on:

    The original article was published in BMC Biotechnology 2021 21:1

  42. The ability of CRISPR/Cas9 to mutate any desired genomic locus is being increasingly explored in the emerging area of cancer immunotherapy. In this respect, current efforts are mostly focused on the use of aut...

    Authors: Elahe Kamali, Fatemeh Rahbarizadeh, Zohreh Hojati and Morten Frödin
    Citation: BMC Biotechnology 2021 21:9
    Content type: Research article Published on:

  43. Nowadays, the number of cancer survivors is significantly increasing as a result of efficient chemo/radio therapeutic treatments. Female cancer survivors may suffer from decreased fertility. In this regard, di...

    Authors: Hossein Nikniaz, Zahra Zandieh, Mohammad Nouri, Neda Daei-farshbaf, Reza Aflatoonian, Mazaher Gholipourmalekabadi and Seyed Behnamedin Jameie
    Citation: BMC Biotechnology 2021 21:8
    Content type: Research article Published on:

  44. Bacterial degradation/transformation of steroids is widely investigated to create biotechnologically relevant strains for industrial application. The strain of Nocardioides simplex VKM Ac-2033D is well known main...

    Authors: Victoria Yu Shtratnikova, Mikhail I. Sсhelkunov, Victoria V. Fokina, Eugeny Y. Bragin, Andrey A. Shutov and Marina V. Donova
    Citation: BMC Biotechnology 2021 21:7
    Content type: Research article Published on:

  45. Microcapsule is considered as a promising 3D microenvironment for Bone Tissue Engineering (BTE) applications. Microencapsulation of cells in an appropriate scaffold not only protected the cells against excess ...

    Authors: Mahdieh Alipour, Nima Firouzi, Zahra Aghazadeh, Mohammad Samiei, Soheila Montazersaheb, Ali Baradar Khoshfetrat and Marziyeh Aghazadeh
    Citation: BMC Biotechnology 2021 21:6
    Content type: Research article Published on:

  47. As bioprocess intensification has increased over the last 30 years, yields from mammalian cell processes have increased from 10’s of milligrams to over 10’s of grams per liter. Most of these gains in productiv...

    Authors: Dylan G. Chitwood, Qinghua Wang, Kathryn Elliott, Aiyana Bullock, Dwon Jordana, Zhigang Li, Cathy Wu, Sarah W. Harcum and Christopher A. Saski
    Citation: BMC Biotechnology 2021 21:4
    Content type: Research article Published on:

  49. The initial step of influenza infection is binding of the virus to specific sialic acid receptors expressed by host cells. This is followed by cell entry via endocytosis. Cleavage of the influenza virus hemagg...

    Authors: Kelly Chungu, Young Hyun Park, Seung Je Woo, Su Bin Lee, Deivendran Rengaraj, Hong Jo Lee and Jae Yong Han
    Citation: BMC Biotechnology 2021 21:2
    Content type: Research article Published on:

  50. Small animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals su...

    Authors: Sanghoon Lee, Min Hee Jung, Kilyoung Song, Jun-Xue Jin, Anukul Taweechaipaisankul, Geon A. Kim, Hyun Ju Oh, Ok Jae Koo, Se Chang Park and Byeong Chun Lee
    Citation: BMC Biotechnology 2021 21:1
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Biotechnology 2021 21:10

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