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Proteomics and drug discovery

Section edited by Igor Stagljar

This section will consider studies that focus on proteomics and protein-protein interactions, and their application in drug discovery, testing and targeting.This section will consider studies that focus on proteomics and protein-protein interactions, and their application in drug discovery, testing and targeting.

  1. In vitro modelling of cancer cells is becoming more complex due to prevailing evidence of intimate interactions between cancer cells and their surrounding stroma. A co-culture system which consists of more tha...

    Authors: Sin-Yeang Teow, Kitson Liew, Mohd Firdaus Che Mat, Marini Marzuki, Norazlin Abdul Aziz, Tai-Lin Chu, Munirah Ahmad and Alan Soo-Beng Khoo

    Citation: BMC Biotechnology 2019 19:34

    Content type: Methodology article

    Published on:

  2. Proteomics is an important tool for the investigation of dynamic physiological responses of microbes under heavy metal stress. To gain insight into how bacteria respond to manganese (II) and identify the prote...

    Authors: Pollyana Santos Queiroz, France Anne Dias Ruas, Natália Rocha Barboza, William de Castro Borges and Renata Guerra-Sá

    Citation: BMC Biotechnology 2018 18:83

    Content type: Research article

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  3. High level of serum fibroblast growth factor 23 (FGF23) is implicated in the development and progression of diabetic nephropathy (DN), making it a crucial factor in the pathogenesis of DN. FGF23 is also tightl...

    Authors: Xiaomin Zhang, Kaiwen Guo, Feng Xia, Xinyu Zhao, Zhifeng Huang and Jianlou Niu

    Citation: BMC Biotechnology 2018 18:33

    Content type: Research article

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  4. Solvate ionic liquids (SILs) are a new class of ionic liquids that are equimolar solutions of lithium bistrifluoromethanesulfonimide in either triglyme or tetraglyme, referred to as G3LiTFSA and G4LiTFSA, resp...

    Authors: Prusothman Yoganantharajah, Alexander P. Ray, Daniel J. Eyckens, Luke C. Henderson and Yann Gibert

    Citation: BMC Biotechnology 2018 18:32

    Content type: Research article

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  5. Celiac disease (CD) is one of the most common food-related chronic disorders. It is mediated by the dietary consumption of prolamins, which are storage proteins of different grains. So far, no therapy exists a...

    Authors: Britta Eggenreich, Elke Scholz, David Johannes Wurm, Florian Forster and Oliver Spadiut

    Citation: BMC Biotechnology 2018 18:30

    Content type: Research article

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  6. Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrate...

    Authors: Christian A. Schaer, Catherine Owczarek, Jeremy W. Deuel, Stefan Schauer, Jin Hyen Baek, Ayla Yalamanoglu, Matthew P. Hardy, Pierre D. Scotney, Peter M. Schmidt, Matthias Pelzing, Peter Soupourmas, Paul W. Buehler and Dominik J. Schaer

    Citation: BMC Biotechnology 2018 18:15

    Content type: Research article

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  7. Targeted delivery of gene therapy vectors to the mouse respiratory tract is often performed via intranasal or intratracheal administration; however, there can be a great deal of variability between these metho...

    Authors: Lisa A. Santry, Joelle C. Ingrao, Darrick L. Yu, Jondavid G. de Jong, Laura P. van Lieshout, Geoffrey A. Wood and Sarah K. Wootton

    Citation: BMC Biotechnology 2017 17:43

    Content type: Methodology article

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  8. G protein-coupled receptors (GPCRs) are ubiquitous surface proteins mediating various biological responses and thus, important targets for therapeutic drugs. GPCRs individually produce their own signaling as w...

    Authors: Yuki Nonobe, Tomoki Yokoyama, Yuji Kamikubo, Sho Yoshida, Nozomi Hisajima, Hiroaki Shinohara, Yuki Shiraishi, Takashi Sakurai and Toshihide Tabata

    Citation: BMC Biotechnology 2016 16:36

    Content type: Methodology article

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  9. Fluorescence-enhancing microarray on plasmonic gold film is an attractive alternative to traditional enzyme-linked immunosorbent assay (ELISA) for cytokine detection because of the increased sensitivity. The a...

    Authors: Manfè Valentina, Fleckner Jan, Nørby Lisby Peder, Zhang Bo, Dai Hongjie and Keller Pernille

    Citation: BMC Biotechnology 2015 15:73

    Content type: Research article

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  10. γ-Glutamyl transpeptidase 1 (GGT1) is an N-glycosylated membrane protein that catabolizes extracellular glutathione and other γ-glutamyl-containing substrates. In a variety of disease states, including tumor form...

    Authors: Matthew B West, Katie Partyka, Christa L Feasley, Kevin A Maupin, Indiwari Goppallawa, Christopher M West, Brian B Haab and Marie H Hanigan

    Citation: BMC Biotechnology 2014 14:101

    Content type: Research article

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  11. So-called cyathane type diterpenoids are produced as secondary metabolites by basidiomycetes. Based on their antibacterial, fungicidal, and cytotoxic properties, cyathane type terpenoids represent interesting ...

    Authors: Tian Shen, Lena M Hof, Heike Hausmann, Marc Stadler and Holger Zorn

    Citation: BMC Biotechnology 2014 14:98

    Content type: Research article

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  12. O. stamineus is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its medicinal value. This study sought to prepare nano liposomes of OS ethanol...

    Authors: Abdalrahim FA Aisha, Amin Malik Shah Abdul Majid and Zhari Ismail

    Citation: BMC Biotechnology 2014 14:23

    Content type: Research article

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  13. Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of ...

    Authors: Xiao-Yun Lu, Ming-Chuan Li, Xin-Liang Zhu, Fan Fan, Lei-Lei Wang and Jian-Gang Ma

    Citation: BMC Biotechnology 2014 14:4

    Content type: Research article

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  14. Monoclonal antibody therapeutics are rapidly gaining in popularity for the treatment of a myriad of diseases, ranging from cancer to autoimmune diseases and neurological diseases. Multiple forms of antibody th...

    Authors: Sean H Gao, Kexin Huang, Hua Tu and Adam S Adler

    Citation: BMC Biotechnology 2013 13:55

    Content type: Research article

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  15. Mitochondrial outer membrane permeabilization (MOMP) is a crucial step leading to apoptotic destruction of cancer cells. Bcl-2 family proteins delicately regulate mitochondrial outer membrane integrity through...

    Authors: Jianting Long, Liu Liu, Zaneta Nikolovska-Coleska, Sanjeev Shangary, Han Yi, Shenming Wang and Shaomeng Wang

    Citation: BMC Biotechnology 2013 13:45

    Content type: Research article

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  16. The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has ...

    Authors: Dennis G Thomas, Sharon Gaheen, Stacey L Harper, Martin Fritts, Fred Klaessig, Elizabeth Hahn-Dantona, David Paik, Sue Pan, Grace A Stafford, Elaine T Freund, Juli D Klemm and Nathan A Baker

    Citation: BMC Biotechnology 2013 13:2

    Content type: Correspondence

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