Proteomics and drug discovery

Section edited by Igor Stagljar

This section will consider studies that focus on proteomics and protein-protein interactions, and their application in drug discovery, testing and targeting.This section will consider studies that focus on proteomics and protein-protein interactions, and their application in drug discovery, testing and targeting.

  1. Methodology article

    AAV vector distribution in the mouse respiratory tract following four different methods of administration

    Targeted delivery of gene therapy vectors to the mouse respiratory tract is often performed via intranasal or intratracheal administration; however, there can be a great deal of variability between these metho...

    Lisa A. Santry, Joelle C. Ingrao, Darrick L. Yu, Jondavid G. de Jong, Laura P. van Lieshout, Geoffrey A. Wood and Sarah K. Wootton

    BMC Biotechnology 2017 17:43

    Published on: 15 May 2017

  2. Methodology article

    Application of surface plasmon resonance imaging to monitoring G protein-coupled receptor signaling and its modulation in a heterologous expression system

    G protein-coupled receptors (GPCRs) are ubiquitous surface proteins mediating various biological responses and thus, important targets for therapeutic drugs. GPCRs individually produce their own signaling as w...

    Yuki Nonobe, Tomoki Yokoyama, Yuji Kamikubo, Sho Yoshida, Nozomi Hisajima, Hiroaki Shinohara, Yuki Shiraishi, Takashi Sakurai and Toshihide Tabata

    BMC Biotechnology 2016 16:36

    Published on: 12 April 2016

  3. Research article

    Cytokine detection and simultaneous assessment of rheumatoid factor interference in human serum and synovial fluid using high-sensitivity protein arrays on plasmonic gold chips

    Fluorescence-enhancing microarray on plasmonic gold film is an attractive alternative to traditional enzyme-linked immunosorbent assay (ELISA) for cytokine detection because of the increased sensitivity. The a...

    Manfè Valentina, Fleckner Jan, Nørby Lisby Peder, Zhang Bo, Dai Hongjie and Keller Pernille

    BMC Biotechnology 2015 15:73

    Published on: 13 August 2015

  4. Research article

    Detection of distinct glycosylation patterns on human γ-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology

    γ-Glutamyl transpeptidase 1 (GGT1) is an N-glycosylated membrane protein that catabolizes extracellular glutathione and other γ-glutamyl-containing substrates. In a variety of disease states, including tumor form...

    Matthew B West, Katie Partyka, Christa L Feasley, Kevin A Maupin, Indiwari Goppallawa, Christopher M West, Brian B Haab and Marie H Hanigan

    BMC Biotechnology 2014 14:101

    Published on: 6 December 2014

  5. Research article

    Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor

    Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of ...

    Xiao-Yun Lu, Ming-Chuan Li, Xin-Liang Zhu, Fan Fan, Lei-Lei Wang and Jian-Gang Ma

    BMC Biotechnology 2014 14:4

    Published on: 18 January 2014

  6. Research article

    Monoclonal antibody humanness score and its applications

    Monoclonal antibody therapeutics are rapidly gaining in popularity for the treatment of a myriad of diseases, ranging from cancer to autoimmune diseases and neurological diseases. Multiple forms of antibody th...

    Sean H Gao, Kexin Huang, Hua Tu and Adam S Adler

    BMC Biotechnology 2013 13:55

    Published on: 5 July 2013

  7. Research article

    Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins

    Mitochondrial outer membrane permeabilization (MOMP) is a crucial step leading to apoptotic destruction of cancer cells. Bcl-2 family proteins delicately regulate mitochondrial outer membrane integrity through...

    Jianting Long, Liu Liu, Zaneta Nikolovska-Coleska, Sanjeev Shangary, Han Yi, Shenming Wang and Shaomeng Wang

    BMC Biotechnology 2013 13:45

    Published on: 24 May 2013

  8. Correspondence

    ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

    The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has ...

    Dennis G Thomas, Sharon Gaheen, Stacey L Harper, Martin Fritts, Fred Klaessig, Elizabeth Hahn-Dantona, David Paik, Sue Pan, Grace A Stafford, Elaine T Freund, Juli D Klemm and Nathan A Baker

    BMC Biotechnology 2013 13:2

    Published on: 14 January 2013