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Microbial biotechnology

This section will consider studies that focus on the genetic manipulation and synthetic/systems biology of bacteria, fungi, yeasts and algae in the context of bioproduction, fermentation, metabolic engineering, biocatalysis, bioremediation and biodegradation.

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  1. More than a dozen of fungal immunomodulatory proteins (FIPs) have been identified to date, most of which are from Ganoderma species. However, little is known about the similarities and differences between differe...

    Authors: Zheng-Wei Qu, Si-Ya Zhou, Shi-Xin Guan, Rui Gao, Zuo-Wen Duan, Xin Zhang, Wei-Yan Sun, Wen-Li Fan, Shui-Sen Chen, Li-Jing Chen, Jing-Wei Lin and Yan-Ye Ruan

    Citation: BMC Biotechnology 2018 18:80

    Content type: Research article

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  2. Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for IB solubilization and subsequent refolding, unfol...

    Authors: Cleide Mara Rosa da Silva, Rosa Maria Chura-Chambi, Lennon Ramos Pereira, Yraima Cordeiro, Luís Carlos de Souza Ferreira and Ligia Morganti

    Citation: BMC Biotechnology 2018 18:78

    Content type: Research article

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  3. Cyclodextrin glucanotransferase (CGTase) can transform L-ascorbic acid (L-AA, vitamin C) to 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G), which shows diverse applications in food, cosmetic and pharmaceutical...

    Authors: Yujia Jiang, Jie Zhou, Ruofan Wu, Fengxue Xin, Wenming Zhang, Yan Fang, Jiangfeng Ma, Weiliang Dong and Min Jiang

    Citation: BMC Biotechnology 2018 18:53

    Content type: Research article

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  5. Arthropod-borne diseases remain a leading cause of human morbidity and mortality and exact an enormous toll on global agriculture. The practice of insecticide-based control is fraught with issues of excessive ...

    Authors: Arinder K. Arora, Kendra N. Pesko, Verónica Quintero-Hernández, Lourival D. Possani, Thomas A. Miller and Ravi V. Durvasula

    Citation: BMC Biotechnology 2018 18:50

    Content type: Research article

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  6. Integration of first- and second-generation ethanol processes is one among the alternate approaches that efficiently address the current socio-economic issues of the bioethanol sector. Edible filamentous fungu...

    Authors: Ramkumar B. Nair, Osagie A. Osadolor, Vamsi K. Ravula, Patrik R. Lennartsson and Mohammad J. Taherzadeh

    Citation: BMC Biotechnology 2018 18:49

    Content type: Research article

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  7. Consolidated bioprocessing (CBP) is a cost-effective approach for the conversion of lignocellulosic biomass to biofuels and biochemicals. The enzymatic conversion of cellulose to glucose requires the synergist...

    Authors: Martinus J. A. Daas, Bart Nijsse, Antonius H. P. van de Weijer, Bart W. A. J. Groenendaal, Fons Janssen, John van der Oost and Richard van Kranenburg

    Citation: BMC Biotechnology 2018 18:42

    Content type: Research article

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  8. β-D-xylosidase is a vital exoglycosidase with the ability to hydrolyze xylooligosaccharides to xylose and to biotransform some saponins by cleaving outer β-xylose. β-D-xylosidase is widely used as one of the x...

    Authors: Qi Li, Tao Wu, Zhipeng Qi, Linguo Zhao, Jianjun Pei and Feng Tang

    Citation: BMC Biotechnology 2018 18:29

    Content type: Research article

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  9. As a very important coenzyme in the cell metabolism, Vitamin B12 (cobalamin, VB12) has been widely used in food and medicine fields. The complete biosynthesis of VB12 requires approximately 30 genes, but overexpr...

    Authors: Yingying Cai, Miaomiao Xia, Huina Dong, Yuan Qian, Tongcun Zhang, Beiwei Zhu, Jinchuan Wu and Dawei Zhang

    Citation: BMC Biotechnology 2018 18:27

    Content type: Research article

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  10. The Baculovirus expression vector system (BEVS) is a transient expression platform for recombinant protein production in insect cells. Baculovirus infection of insect cells will shutoff host translation and in...

    Authors: Xiaoyue Zhang, Keyan Xu, Yanmei Ou, Xiaodong Xu and Hongying Chen

    Citation: BMC Biotechnology 2018 18:24

    Content type: Research article

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  11. Arachidonic acid (ARA), which is a ω-6 polyunsaturated fatty acid, has a wide range of biological activities and is an essential component of cellular membranes in some human tissues. Mortierella alpina is the be...

    Authors: Huidan Zhang, Dong Lu, Xin Li, Yingang Feng, Qiu Cui and Xiaojin Song

    Citation: BMC Biotechnology 2018 18:23

    Content type: Research article

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  12. Violacein is a deep violet compound that is produced by a number of bacterial species. It is synthesized from tryptophan by a pathway that involves the sequential action of 5 different enzymes (encoded by genes v...

    Authors: Elizabeth Bilsland, Tatyana A. Tavella, Renata Krogh, Jamie E. Stokes, Annabelle Roberts, James Ajioka, David R. Spring, Adriano D. Andricopulo, Fabio T. M. Costa and Stephen G. Oliver

    Citation: BMC Biotechnology 2018 18:22

    Content type: Research article

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  13. Thermostable phosphotriesterase-like lactonases (PLLs) are able to degrade organophosphates and could be potentially employed as bioremediation tools and bioscavengers. But nowadays their manufacturing in high...

    Authors: Odile Francesca Restaino, Maria Giovanna Borzacchiello, Ilaria Scognamiglio, Luigi Fedele, Alberto Alfano, Elena Porzio, Giuseppe Manco, Mario De Rosa and Chiara Schiraldi

    Citation: BMC Biotechnology 2018 18:18

    Content type: Research article

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  14. Filamentous bacteria of the genus Streptomyces produce a large arsenal of industrially relevant antibiotics and enzymes. The industrial production of these molecules occurs in large fermenters, where many strepto...

    Authors: Boris Zacchetti, Agathoklis Andrianos, Dino van Dissel, Evelien de Ruiter, Gilles P. van Wezel and Dennis Claessen

    Citation: BMC Biotechnology 2018 18:13

    Content type: Research article

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  15. Chlamydomonas reinhardtii is an unicellular green alga used for functional genomics studies and heterologous protein expression. A major hindrance in these studies is the low level and instability of expression o...

    Authors: Paola Mini, Olivia Costantina Demurtas, Silvia Valentini, Patrizia Pallara, Giuseppe Aprea, Paola Ferrante and Giovanni Giuliano

    Citation: BMC Biotechnology 2018 18:11

    Content type: Research article

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  16. L-phenylalanine (L-Phe) is an essential amino acid for mammals and applications expand into human health and nutritional products. In this study, a system level engineering was conducted to enhance L-Phe biosy...

    Authors: Yongfei Liu, Yiran Xu, Dongqin Ding, Jianping Wen, Beiwei Zhu and Dawei Zhang

    Citation: BMC Biotechnology 2018 18:5

    Content type: Research article

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  17. Receptor activator of NF-κB ligand (RANKL)/RANK signaling essentially functions within the skeletal system, particularly participating in osteoclastogenesis and bone resorption. In addition, this signaling pat...

    Authors: Yilei Wei, Yu Zhan, Pengfei Chen, Zhi Liu, Haohao Zhang, Dandan Liu, Jie Zhang, Min Yu, Wei Mo, Jun Zhang and Xiaoren Zhang

    Citation: BMC Biotechnology 2017 17:87

    Content type: Research article

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  18. Starch-binding domains from carbohydrate binding module family 20 have been used as a tool for starch engineering. Previous studies showed that

    Authors: Xing-Feng Huang, Farhad Nazarian, Jean-Paul Vincken, Richard G. F. Visser and Luisa M. Trindade

    Citation: BMC Biotechnology 2017 17:86

    Content type: Research article

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  19. When the unavoidable waste generation is considered as damaging to our environment, it becomes crucial to develop a sustainable technology to remediate the pollutant source towards an environmental protection ...

    Authors: Arezoo Dadrasnia, Mohd Sofian Azirun and Salmah Binti Ismail

    Citation: BMC Biotechnology 2017 17:85

    Content type: Research article

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  20. The identification of microorganisms with excellent flocculant-producing capability and optimization of the fermentation process are necessary for the wide-scale application of bioflocculants. Thus, we evaluat...

    Authors: Zhen Chen, Zhipeng Li, Peize Liu, Yu Liu, Yuanpeng Wang, Qingbiao Li and Ning He

    Citation: BMC Biotechnology 2017 17:84

    Content type: Research article

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  21. Recent development of DNA assembly technologies has spurred myriad advances in synthetic biology, but new tools are always required for complicated scenarios. Here, we have developed an alternative DNA assembl...

    Authors: Fanli Zeng, Jinping Zang, Suhua Zhang, Zhimin Hao, Jingao Dong and Yibin Lin

    Citation: BMC Biotechnology 2017 17:81

    Content type: Methodology article

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  22. There is a need for the development of synthetic biology methods and tools to facilitate rapid and efficient engineering of yeast that accommodates the needs of specific biotechnology projects. In particular, ...

    Authors: Ana Pérez-González, Ryan Kniewel, Marcel Veldhuizen, Hemant K. Verma, Mónica Navarro-Rodríguez, Luis M. Rubio and Elena Caro

    Citation: BMC Biotechnology 2017 17:80

    Content type: Methodology article

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  23. Pichia guilliermondii was found capable of expressing the recombinant thermostable lipase without methanol under the control of methanol dependent alcohol oxidase 1 promoter (AOXp 1). ...

    Authors: Mary Ladidi Abu, Hisham Mohd Nooh, Siti Nurbaya Oslan and Abu Bakar Salleh

    Citation: BMC Biotechnology 2017 17:78

    Content type: Research article

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  24. The myxomycetes derive their common name (slime molds) from the multinucleate trophic stage (plasmodium) in the life cycle, which typically produces a noticeable amount of slimy materials, some of which is nor...

    Authors: Tuyen T.M Huynh, Trung V. Phung, Steven L. Stephenson and Hanh T.M Tran

    Citation: BMC Biotechnology 2017 17:76

    Content type: Research article

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  25. β-Glucosidase has attracted substantial attention in the scientific community because of its pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. However, the te...

    Authors: Fei Chang, Xianbing Zhang, Yu Pan, Youxue Lu, Wei Fang, Zemin Fang and Yazhong Xiao

    Citation: BMC Biotechnology 2017 17:74

    Content type: Research article

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  26. Second-generation ethanol production is a clean bioenergy source with potential to mitigate fossil fuel emissions. The engineering of Saccharomyces cerevisiae for xylose utilization is an essential step towards t...

    Authors: Beatriz Temer, Leandro Vieira dos Santos, Victor Augusti Negri, Juliana Pimentel Galhardo, Pedro Henrique Mello Magalhães, Juliana José, Cidnei Marschalk, Thamy Lívia Ribeiro Corrêa, Marcelo Falsarella Carazzolle and Gonçalo Amarante Guimarães Pereira

    Citation: BMC Biotechnology 2017 17:71

    Content type: Research article

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  27. Arachidonic acid (ARA, C20:4, n-6), which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities, is commercially produced in Mortierella alpina. Dissolved oxygen ...

    Authors: Huidan Zhang, Yingang Feng, Qiu Cui and Xiaojin Song

    Citation: BMC Biotechnology 2017 17:68

    Content type: Research article

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  28. Acetic acid is a predominant by-product of lignocellulosic biofuel process, which inhibits microbial biocatalysts. Development of bacterial strains that are tolerant to acetic acid is challenging due to poor u...

    Authors: Yu-Fan Liu, Chia-Wen Hsieh, Yao-Sheng Chang and Being-Sun Wung

    Citation: BMC Biotechnology 2017 17:63

    Content type: Research article

    Published on:

  29. Direct manipulation of the genome is a widespread technique for genetic studies and synthetic biology applications. The tyrosine and serine site-specific recombination systems of bacteriophages HK022 and ΦC31 ...

    Authors: Michael J. Bland, Magaly Ducos-Galand, Marie-Eve Val and Didier Mazel

    Citation: BMC Biotechnology 2017 17:62

    Content type: Methodology article

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  30. Dissolved oxygen tension (DOT) is hardly constant and homogenously distributed in a bioreactor, which can have a negative impact in the metabolism and product synthesis. However, the effects of DOT on plasmid ...

    Authors: Karim E. Jaén, Juan-Carlos Sigala, Roberto Olivares-Hernández, Karsten Niehaus and Alvaro R. Lara

    Citation: BMC Biotechnology 2017 17:60

    Content type: Research article

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  31. The environmental gliding bacteria Lysobacter are emerging as a new group of biocontrol agents due to their prolific production of lytic enzymes and potent antibiotic natural products. These bacteria are intrinsi...

    Authors: Wei Zhang, Justin Huffman, Shengying Li, Yuemao Shen and Liangcheng Du

    Citation: BMC Biotechnology 2017 17:59

    Content type: Research article

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  32. The discharge of poorly treated effluents into the environment has far reaching, consequential impacts on human and aquatic life forms. Thus, we evaluated the flocculating efficiency of our test bioflocculant ...

    Authors: Mayowa Oladele Agunbiade, Esta Van Heerden, Carolina H. Pohl and Anofi Tom Ashafa

    Citation: BMC Biotechnology 2017 17:51

    Content type: Research article

    Published on:

  33. Whey permeate is a lactose-rich effluent remaining after protein extraction from milk-resulting cheese whey, an abundant dairy waste. The lactose to ethanol fermentation can complete whey valorization chain by...

    Authors: Lorenzo Pasotti, Susanna Zucca, Michela Casanova, Giuseppina Micoli, Maria Gabriella Cusella De Angelis and Paolo Magni

    Citation: BMC Biotechnology 2017 17:48

    Content type: Research article

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  35. Endo-xylanases are essential in degrading hemicellulose of various lignocellulosic substrates. Hemicellulose degradation by Geobacillus spp. is facilitated by the hemicellulose utilization (HUS) locus that is pre...

    Authors: Martinus J.A. Daas, Patricia Murciano Martínez, Antonius H.P. van de Weijer, John van der Oost, Willem M. de Vos, Mirjam A. Kabel and Richard van Kranenburg

    Citation: BMC Biotechnology 2017 17:44

    Content type: Research article

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  36. At first glance, there appears to be a high degree of similarity between the metabolism of yeast (the Crabtree effect) and human cancer cells (the Warburg effect). At the root of both effects is accelerated me...

    Authors: Darjan Andrejc, Alenka Možir and Matic Legiša

    Citation: BMC Biotechnology 2017 17:41

    Content type: Research Article

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  37. Propionate is widely used as an important preservative and important chemical intermediate for synthesis of cellulose fibers, herbicides, perfumes and pharmaceuticals. Biosynthetic propionate has mainly been p...

    Authors: Jing Li, Xinna Zhu, Jing Chen, Dongdong Zhao, Xueli Zhang and Changhao Bi

    Citation: BMC Biotechnology 2017 17:38

    Content type: Research article

    Published on:

  38. N-Butanol has favorable characteristics for use as either an alternative fuel or platform chemical. Bio-based n-butanol production using microbes is an emerging technology that requires further development. Al...

    Authors: Wei-Chih Chin, Kuo-Hsing Lin, Chun-Chi Liu, Kenji Tsuge and Chieh-Chen Huang

    Citation: BMC Biotechnology 2017 17:36

    Content type: Research article

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  40. Restriction-free (RF) cloning, a PCR-based method for the creation of custom DNA plasmids, allows for the insertion of any sequence into any plasmid vector at any desired position, independent of restriction s...

    Authors: Fanli Zeng, Zhimin Hao, Pan Li, Yanan Meng, Jingao Dong and Yibin Lin

    Citation: BMC Biotechnology 2017 17:32

    Content type: Methodology article

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  42. Oleaginous organisms are a promising, renewable source of single cell oil. Lipid accumulation is mainly induced by limitation of nutrients such as nitrogen, phosphorus or sulfur. The oleaginous yeast Trichosporon...

    Authors: Felix Bracharz, Veronika Redai, Kathrin Bach, Farah Qoura and Thomas Brück

    Citation: BMC Biotechnology 2017 17:27

    Content type: Research article

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  43. Recent researches have been focusing on mucosal immune adjuvants, which play the key roles in mucosal immunization and have become the limitation for non-injected vaccine development. Escherichia coli heat-labile...

    Authors: Nan Sun, Rongguang Zhang, Guangcai Duan, Xiaoyan Peng, Chen Wang, Qingtang Fan, Shuaiyin Chen and Yuanlin Xi

    Citation: BMC Biotechnology 2017 17:25

    Content type: Research article

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  44. poly(L-malic acid) (PMA) is a water-soluble polyester with many attractive properties in medicine and food industries, but the high cost of PMA fermentation has restricted its further application for large-sca...

    Authors: Jun Xia, Jiaxing Xu, Xiaoyan Liu, Jiming Xu, Xingfeng Wang and Xiangqian Li

    Citation: BMC Biotechnology 2017 17:20

    Content type: Research article

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  45. Manganese peroxidase (MnP) of white rot basidiomycetes, an extracellular heme enzyme, is part of a peroxidase superfamily that is capable of degrading the different phenolic compounds. Ganoderma, a white rot basi...

    Authors: Hui Xu, Meng-Yuan Guo, Yan-Hua Gao, Xiao-Hui Bai and Xuan-Wei Zhou

    Citation: BMC Biotechnology 2017 17:19

    Content type: Research article

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  46. Multi-copy gene integration into microbial genomes is a conventional tool for obtaining improved gene expression. For Penicillium chrysogenum, the fungal producer of the beta-lactam antibiotic penicillin, many pr...

    Authors: Sandra Ziemons, Katerina Koutsantas, Kordula Becker, Tim Dahlmann and Ulrich Kück

    Citation: BMC Biotechnology 2017 17:16

    Content type: Research article

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  49. Initially known as the reproductive hormone, relaxin was shown to possess other therapeutically useful properties that include extracellular matrix remodeling, anti-inflammatory, anti-ischemic and angiogenic e...

    Authors: D. Cimini, K. Della Corte, R. Finamore, L. Andreozzi, A. Stellavato, A. V. A. Pirozzi, F. Ferrara, R. Formisano, M. De Rosa, M. Chino, L. Lista, A. Lombardi, V. Pavone and C. Schiraldi

    Citation: BMC Biotechnology 2017 17:4

    Content type: Research article

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  50. Tobacco stalk is one kind of abundant crop residues in China. The high lignification of tobacco stalk increases its reusing cost and the existing of nicotine will cause serious pollution. The biodegradation of...

    Authors: Yulong Su, He Xian, Sujuan Shi, Chengsheng Zhang, S. M. Nuruzzaman Manik, Jingjing Mao, Ge Zhang, Weihong Liao, Qian Wang and Haobao Liu

    Citation: BMC Biotechnology 2016 16:81

    Content type: Research article

    Published on:

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