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Microbial biotechnology

Section edited by Peter J Punt and Dennis Claessen

This section will consider studies that focus on the genetic manipulation and synthetic/systems biology of bacteria, fungi, yeasts and algae in the context of bioproduction, fermentation, metabolic engineering, biocatalysis, bioremediation and biodegradation.

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  1. Cellulosic biomass degradation still needs to be paid more attentions as bioenergy is the most likely to replace fossil energy in the future, and more evaluable cellulolytic bacteria isolation will lay a found...

    Authors: Lingling Ma, Yingying Lu, Hong Yan, Xin Wang, Yanglei Yi, Yuanyuan Shan, Bianfang Liu, Yuan Zhou and Xin Lü

    Citation: BMC Biotechnology 2020 20:2

    Content type: Research article

    Published on:

  2. Rapeseed cake (RSC), as the intermediate by-product of oil extraction from the seeds of Brassica napus, can be converted into rapeseed meal (RSM) by solvent extraction to remove oil. However, compared with RSM, R...

    Authors: Wenchao Chen, Xuan Li, Xuli Ma, Shouwen Chen, Yanping Kang, Minmin Yang, Fenghong Huang and Xia Wan

    Citation: BMC Biotechnology 2019 19:98

    Content type: Research article

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  3. The traditional method of bacterial identification based on 16S rRNA is a widely used and very effective detection method, but this method still has some deficiencies, especially in the identification of close...

    Authors: Xiaoyang Pang, Ziyang Jia, Jing Lu, Shuwen Zhang, Cai Zhang, Min Zhang and Jiaping Lv

    Citation: BMC Biotechnology 2019 19:87

    Content type: Research article

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  4. Site-specific integration system allows foreign DNA to be integrated into the specific site of the host genome, enabling stable expression of heterologous protein. In this study, integrative vectors for secret...

    Authors: Innanurdiani Koko, Adelene Ai-Lian Song, Mas Jaffri Masarudin and Raha Abdul Rahim

    Citation: BMC Biotechnology 2019 19:82

    Content type: Research article

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  5. Corynebacterium ammoniagenes is an important industrial organism that is widely used to produce nucleotides and the potential for industrial production of coenzyme A by C. ammoniagenes ATCC 6871 has been shown. H...

    Authors: Yingshuo Hou, Siyu Chen, Jianjun Wang, Guizhen Liu, Sheng Wu and Yong Tao

    Citation: BMC Biotechnology 2019 19:76

    Content type: Research article

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  6. In filamentous fungi, transport of organic acids across the mitochondrial membrane is facilitated by active transport via shuttle proteins. These transporters may transfer different organic acids across the me...

    Authors: Lei Yang, Tore Linde, Abeer H. Hossain, Mette Lübeck, Peter J. Punt and Peter S. Lübeck

    Citation: BMC Biotechnology 2019 19:72

    Content type: Research article

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  7. Aspergillus oryzae, a useful industrial filamentous fungus, produces limited varieties of secondary metabolites, such as kojic acid. Thus, for the production of valuable secondary metabolites by genetic engineeri...

    Authors: Koichi Tamano, Mahoko Kuninaga, Naoshi Kojima, Myco Umemura, Masayuki Machida and Hideaki Koike

    Citation: BMC Biotechnology 2019 19:70

    Content type: Research article

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  8. The textural characteristics of fermented dairy products are important quality parameters that play a major role in their stability and consumer’s acceptance. The aim of this study was to investigate the influ...

    Authors: Soumaya El Bouchikhi, Philippe Pagès, Yassir El Alaoui, Azeddine Ibrahimi and Yahya Bensouda

    Citation: BMC Biotechnology 2019 19:57

    Content type: Research article

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  9. The microbial transglutaminase (MTG) is inactive when only the mature sequence is expressed in Pichia pastoris. Although co-expression of MTG and its N-terminal pro-peptide can obtain the active MTG, the enzyme a...

    Authors: Xiaoping Song, Changsheng Shao, Yugang Guo, Yajie Wang and Jingjing Cai

    Citation: BMC Biotechnology 2019 19:54

    Content type: Research article

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  10. Increasing CO2 emissions have resulted in ocean acidification, affecting marine plant photosynthesis and changing the nutrient composition of marine ecosystems. The physiological and biochemical processes of mari...

    Authors: Aiyou Huang, Songcui Wu, Wenhui Gu, Yuanxiang Li, Xiujun Xie and Guangce Wang

    Citation: BMC Biotechnology 2019 19:53

    Content type: Research article

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  11. Packing materials is a critical design consideration when employing biological reactor to treat malodorous gases. The acidification of packing bed usually results in a significant drop in the removal efficienc...

    Authors: Xiang Tu, Meiying Xu, Jianjun Li, Enze Li, Rongfang Feng, Gang Zhao, Shaobin Huang and Jun Guo

    Citation: BMC Biotechnology 2019 19:52

    Content type: Research article

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  12. S-Phenyl-L-cysteine is regarded as having potential applicability as an antiretroviral/protease inhibitor for human immunodeficiency virus (HIV). In the present study, optically active S-phenyl-L-cysteine was pre...

    Authors: Lisheng Xu, Xingtao Zhang, Guizhen Gao and Sun Yue

    Citation: BMC Biotechnology 2019 19:49

    Content type: Research article

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  13. Natamycin is an antifungal polyene macrolide antibiotic with wide applications in health and food industries. Currently, it is the only antifungal food additive with the GRAS status (Generally Regarded as Safe).

    Authors: Elsayed Ahmed Elsayed, Mohamed A. Farid and Hesham A. El-Enshasy

    Citation: BMC Biotechnology 2019 19:46

    Content type: Research article

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  14. Tobacco stalk (TS), a major agricultural waste abundant in pectin, has resulted in concerns about the need for its reuse. The nicotine in TS is considered a chemical that is to\xic and hazardous to the environ...

    Authors: Ge Zhang, Shugui Li, Yingbo Xu, Juan Wang, Fan Wang, Yuhua Xin, Zhong Shen, Haibo Zhang, Ming Ma and Haobao Liu

    Citation: BMC Biotechnology 2019 19:45

    Content type: Research article

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  15. Pythium irregulare is an oleaginous Oomycete able to accumulate large amounts of lipids, including Eicosapentaenoic acid (EPA). EPA is an important and expensive dietary supplement with a promising and very compe...

    Authors: Bruna S. Fernandes, Oscar Dias, Gisela Costa, Antonio A. Kaupert Neto, Tiago F. C. Resende, Juliana V. C. Oliveira, Diego M. Riaño-Pachón, Marcelo Zaiat, José G. C. Pradella and Isabel Rocha

    Citation: BMC Biotechnology 2019 19:41

    Content type: Research article

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  16. Aerobic side chain degradation of phytosterols by actinobacteria is the basis for the industrial production of androstane steroids which are the starting materials for the synthesis of steroid hormones. A nati...

    Authors: Eugeny Y. Bragin, Victoria Y. Shtratnikova, Mikhail I. Schelkunov, Dmitry V. Dovbnya and Marina V. Donova

    Citation: BMC Biotechnology 2019 19:39

    Content type: Research article

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  18. Few natural product pathways from rare Actinomycetes have been studied due to the difficulty in applying molecular approaches in these genetically intractable organisms. In this study, we sought to identify mo...

    Authors: Hong Gao, Buvani Murugesan, Janina Hoßbach, Stephanie K. Evans, W. Marshall Stark and Margaret C. M. Smith

    Citation: BMC Biotechnology 2019 19:32

    Content type: Research article

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  19. The potassium dichromate oxidation method used in determination of alcohols in fermentation has two major disadvantages. This method cannot be used to determine alcohols in raw fermentation broth samples, whic...

    Authors: Peng Zhang, Hao Hai, Dongxu Sun, Weihua Yuan, Weijie Liu, Ruru Ding, Mengting Teng, Lin Ma, Jun Tian and Caifa Chen

    Citation: BMC Biotechnology 2019 19:30

    Content type: Methodology article

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  20. The current limitations of conventional BCG vaccines highlights the importance in developing novel and effective vaccines against tuberculosis (TB). The utilization of probiotics such as Lactobacillus plantarum f...

    Authors: Anhar Danial Mustafa, Jeevanathan Kalyanasundram, Sarah Sabidi, Adelene Ai-Lian Song, Maha Abdullah, Raha Abdul Rahim and Khatijah Yusoff

    Citation: BMC Biotechnology 2019 19:27

    Content type: Methodology article

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  21. Protein solubility characteristics are important determinants of success for recombinant proteins in relation to expression, purification, storage and administration. Escherichia coli offers a cost-efficient expr...

    Authors: M. Alejandro Carballo-Amador, Edward A. McKenzie, Alan J. Dickson and Jim Warwicker

    Citation: BMC Biotechnology 2019 19:26

    Content type: Research article

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  22. The importance of the accessory enzymes such as α-L-arabinofuranosidases (AFases) in synergistic interactions within cellulolytic mixtures has introduced a paradigm shift in the search for hydrolytic enzymes. ...

    Authors: Brent Fortune, Sizwe Mhlongo, Leonardo Joaquim van Zyl, Robert Huddy, Mariette Smart and Marla Trindade

    Citation: BMC Biotechnology 2019 19:22

    Content type: Research article

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  23. The CRISPR/Cas (clustered regularly interspaced short palindromic repeat and CRISPR-associated nucleases) based technologies have revolutionized genome engineering. While their use for prokaryotic genome editi...

    Authors: Soumaya Najah, Corinne Saulnier, Jean-Luc Pernodet and Stéphanie Bury-Moné

    Citation: BMC Biotechnology 2019 19:18

    Content type: Methodology article

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  24. Parageobacillus thermoglucosidasius is a thermophilic and ethanol-producing bacterium capable of utilising both hexose and pentose sugars for fermentation. The organism has been proposed to be a suitable organism...

    Authors: Alexandria T. N. Holland, Michael J. Danson and Albert Bolhuis

    Citation: BMC Biotechnology 2019 19:17

    Content type: Research article

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  25. Despite the growing demand for antimicrobial peptides (AMPs) for clinical use as an alternative approach against antibiotic-resistant bacteria, the manufacture of AMPs relies on expensive, small-scale chemical...

    Authors: Da Sol Kim, Seon Woong Kim, Jae Min Song, Soon Young Kim and Kwang-Chul Kwon

    Citation: BMC Biotechnology 2019 19:13

    Content type: Research article

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  26. Citric acid is considered as the most economically feasible product of microbiological production, therefore studies on cheap and renewable raw materials for its production are highly desirable. In this study ...

    Authors: Magdalena Rakicka, Jakub Wolniak, Zbigniew Lazar and Waldemar Rymowicz

    Citation: BMC Biotechnology 2019 19:11

    Content type: Research article

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  27. We aimed at constructing Lactococcus lactis strains expressing HPV-16 recombinant E7 (rE7) oncoprotein and examining its overproduction ability followed by optimizing batch and fed-batch fermentations. Thereafter...

    Authors: Amir Hossein Mohseni, Sedigheh Taghinezhad-S, Hossein Keyvani and Vadood Razavilar

    Citation: BMC Biotechnology 2019 19:8

    Content type: Research article

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  28. Synechocystis sp. PCC 6803 is a photosynthetic bacterium that has been genetically modified to produce industrially relevant chemicals, yet efflux mechanisms have not been well elucidated. These photosynthetic or...

    Authors: Matthew P. A. Bellefleur, Soo-Young Wanda and Roy Curtiss III

    Citation: BMC Biotechnology 2019 19:5

    Content type: Research article

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    The Correction to this article has been published in BMC Biotechnology 2019 19:12

  29. A promoter that drives high-level, long-term expression of the target gene under substrate limited growth conditions in the absence of an artificial inducer would facilitate the efficient production of heterol...

    Authors: Nguyen Thanh Trung, Nguyen Minh Hung, Nguyen Huy Thuan, Nguyen Xuan Canh, Thomas Schweder and Britta Jürgen

    Citation: BMC Biotechnology 2019 19:3

    Content type: Research article

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  30. The methanol-regulated AOX1 promoter (PAOX1) is the most widely used promoter in the production of recombinant proteins in the methylotrophic yeast Pichia pastoris. However, as the tight regulation and methanol d...

    Authors: Ching-Hsiang Chang, Hao-An Hsiung, Kai-Lin Hong and Ching-Tsan Huang

    Citation: BMC Biotechnology 2018 18:81

    Content type: Research article

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  31. More than a dozen of fungal immunomodulatory proteins (FIPs) have been identified to date, most of which are from Ganoderma species. However, little is known about the similarities and differences between differe...

    Authors: Zheng-Wei Qu, Si-Ya Zhou, Shi-Xin Guan, Rui Gao, Zuo-Wen Duan, Xin Zhang, Wei-Yan Sun, Wen-Li Fan, Shui-Sen Chen, Li-Jing Chen, Jing-Wei Lin and Yan-Ye Ruan

    Citation: BMC Biotechnology 2018 18:80

    Content type: Research article

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  32. Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for IB solubilization and subsequent refolding, unfol...

    Authors: Cleide Mara Rosa da Silva, Rosa Maria Chura-Chambi, Lennon Ramos Pereira, Yraima Cordeiro, Luís Carlos de Souza Ferreira and Ligia Morganti

    Citation: BMC Biotechnology 2018 18:78

    Content type: Research article

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  33. Cyclodextrin glucanotransferase (CGTase) can transform L-ascorbic acid (L-AA, vitamin C) to 2-O-α-D-glucopyranosyl-L-ascorbic acid (AA-2G), which shows diverse applications in food, cosmetic and pharmaceutical...

    Authors: Yujia Jiang, Jie Zhou, Ruofan Wu, Fengxue Xin, Wenming Zhang, Yan Fang, Jiangfeng Ma, Weiliang Dong and Min Jiang

    Citation: BMC Biotechnology 2018 18:53

    Content type: Research article

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  35. Arthropod-borne diseases remain a leading cause of human morbidity and mortality and exact an enormous toll on global agriculture. The practice of insecticide-based control is fraught with issues of excessive ...

    Authors: Arinder K. Arora, Kendra N. Pesko, Verónica Quintero-Hernández, Lourival D. Possani, Thomas A. Miller and Ravi V. Durvasula

    Citation: BMC Biotechnology 2018 18:50

    Content type: Research article

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  36. Integration of first- and second-generation ethanol processes is one among the alternate approaches that efficiently address the current socio-economic issues of the bioethanol sector. Edible filamentous fungu...

    Authors: Ramkumar B. Nair, Osagie A. Osadolor, Vamsi K. Ravula, Patrik R. Lennartsson and Mohammad J. Taherzadeh

    Citation: BMC Biotechnology 2018 18:49

    Content type: Research article

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  37. Consolidated bioprocessing (CBP) is a cost-effective approach for the conversion of lignocellulosic biomass to biofuels and biochemicals. The enzymatic conversion of cellulose to glucose requires the synergist...

    Authors: Martinus J. A. Daas, Bart Nijsse, Antonius H. P. van de Weijer, Bart W. A. J. Groenendaal, Fons Janssen, John van der Oost and Richard van Kranenburg

    Citation: BMC Biotechnology 2018 18:42

    Content type: Research article

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  38. β-D-xylosidase is a vital exoglycosidase with the ability to hydrolyze xylooligosaccharides to xylose and to biotransform some saponins by cleaving outer β-xylose. β-D-xylosidase is widely used as one of the x...

    Authors: Qi Li, Tao Wu, Zhipeng Qi, Linguo Zhao, Jianjun Pei and Feng Tang

    Citation: BMC Biotechnology 2018 18:29

    Content type: Research article

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  39. As a very important coenzyme in the cell metabolism, Vitamin B12 (cobalamin, VB12) has been widely used in food and medicine fields. The complete biosynthesis of VB12 requires approximately 30 genes, but overexpr...

    Authors: Yingying Cai, Miaomiao Xia, Huina Dong, Yuan Qian, Tongcun Zhang, Beiwei Zhu, Jinchuan Wu and Dawei Zhang

    Citation: BMC Biotechnology 2018 18:27

    Content type: Research article

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  40. The Baculovirus expression vector system (BEVS) is a transient expression platform for recombinant protein production in insect cells. Baculovirus infection of insect cells will shutoff host translation and in...

    Authors: Xiaoyue Zhang, Keyan Xu, Yanmei Ou, Xiaodong Xu and Hongying Chen

    Citation: BMC Biotechnology 2018 18:24

    Content type: Research article

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  41. Arachidonic acid (ARA), which is a ω-6 polyunsaturated fatty acid, has a wide range of biological activities and is an essential component of cellular membranes in some human tissues. Mortierella alpina is the be...

    Authors: Huidan Zhang, Dong Lu, Xin Li, Yingang Feng, Qiu Cui and Xiaojin Song

    Citation: BMC Biotechnology 2018 18:23

    Content type: Research article

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  42. Violacein is a deep violet compound that is produced by a number of bacterial species. It is synthesized from tryptophan by a pathway that involves the sequential action of 5 different enzymes (encoded by genes v...

    Authors: Elizabeth Bilsland, Tatyana A. Tavella, Renata Krogh, Jamie E. Stokes, Annabelle Roberts, James Ajioka, David R. Spring, Adriano D. Andricopulo, Fabio T. M. Costa and Stephen G. Oliver

    Citation: BMC Biotechnology 2018 18:22

    Content type: Research article

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  43. Thermostable phosphotriesterase-like lactonases (PLLs) are able to degrade organophosphates and could be potentially employed as bioremediation tools and bioscavengers. But nowadays their manufacturing in high...

    Authors: Odile Francesca Restaino, Maria Giovanna Borzacchiello, Ilaria Scognamiglio, Luigi Fedele, Alberto Alfano, Elena Porzio, Giuseppe Manco, Mario De Rosa and Chiara Schiraldi

    Citation: BMC Biotechnology 2018 18:18

    Content type: Research article

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  44. Filamentous bacteria of the genus Streptomyces produce a large arsenal of industrially relevant antibiotics and enzymes. The industrial production of these molecules occurs in large fermenters, where many strepto...

    Authors: Boris Zacchetti, Agathoklis Andrianos, Dino van Dissel, Evelien de Ruiter, Gilles P. van Wezel and Dennis Claessen

    Citation: BMC Biotechnology 2018 18:13

    Content type: Research article

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  45. Chlamydomonas reinhardtii is an unicellular green alga used for functional genomics studies and heterologous protein expression. A major hindrance in these studies is the low level and instability of expression o...

    Authors: Paola Mini, Olivia Costantina Demurtas, Silvia Valentini, Patrizia Pallara, Giuseppe Aprea, Paola Ferrante and Giovanni Giuliano

    Citation: BMC Biotechnology 2018 18:11

    Content type: Research article

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  46. L-phenylalanine (L-Phe) is an essential amino acid for mammals and applications expand into human health and nutritional products. In this study, a system level engineering was conducted to enhance L-Phe biosy...

    Authors: Yongfei Liu, Yiran Xu, Dongqin Ding, Jianping Wen, Beiwei Zhu and Dawei Zhang

    Citation: BMC Biotechnology 2018 18:5

    Content type: Research article

    Published on:

  47. Receptor activator of NF-κB ligand (RANKL)/RANK signaling essentially functions within the skeletal system, particularly participating in osteoclastogenesis and bone resorption. In addition, this signaling pat...

    Authors: Yilei Wei, Yu Zhan, Pengfei Chen, Zhi Liu, Haohao Zhang, Dandan Liu, Jie Zhang, Min Yu, Wei Mo, Jun Zhang and Xiaoren Zhang

    Citation: BMC Biotechnology 2017 17:87

    Content type: Research article

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  48. Starch-binding domains from carbohydrate binding module family 20 have been used as a tool for starch engineering. Previous studies showed that

    Authors: Xing-Feng Huang, Farhad Nazarian, Jean-Paul Vincken, Richard G. F. Visser and Luisa M. Trindade

    Citation: BMC Biotechnology 2017 17:86

    Content type: Research article

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  49. When the unavoidable waste generation is considered as damaging to our environment, it becomes crucial to develop a sustainable technology to remediate the pollutant source towards an environmental protection ...

    Authors: Arezoo Dadrasnia, Mohd Sofian Azirun and Salmah Binti Ismail

    Citation: BMC Biotechnology 2017 17:85

    Content type: Research article

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  50. The identification of microorganisms with excellent flocculant-producing capability and optimization of the fermentation process are necessary for the wide-scale application of bioflocculants. Thus, we evaluat...

    Authors: Zhen Chen, Zhipeng Li, Peize Liu, Yu Liu, Yuanpeng Wang, Qingbiao Li and Ning He

    Citation: BMC Biotechnology 2017 17:84

    Content type: Research article

    Published on:

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