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Cellular and tissue engineering

This section will consider articles that relate to stem cell research and regenerative medicine as well as cell culture methods and bioproduction in animal cells.


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  1. Normal development and the response to injury both require cell growth, migration and morphological remodeling, guided by a complex local landscape of permissive and inhibitory cues. A standard approach for st...

    Authors: Wiam Belkaid, Peter Thostrup, Patricia T Yam, Camille A Juzwik, Edward S Ruthazer, Ajit S Dhaunchak and David R Colman

    Citation: BMC Biotechnology 2013 13:86

    Content type: Research article

    Published on:

  3. Common cell based strategies for the treatment of osseous defects require the isolation and expansion of autologous cells. Since this makes such approaches time-consuming and expensive, we developed a novel ex...

    Authors: Oliver B Betz, Volker M Betz, Christian Schröder, Rainer Penzkofer, Michael Göttlinger, Susanne Mayer-Wagner, Peter Augat, Volkmar Jansson and Peter E Müller

    Citation: BMC Biotechnology 2013 13:65

    Content type: Research article

    Published on:

  4. There is considerable interest in using cell sheets for the treatment of various lesions as part of regenerative medicine therapy. Cell sheets can be prepared in temperature-responsive culture dishes and appli...

    Authors: Miki Maehara, Masato Sato, Masahito Watanabe, Hitomi Matsunari, Mami Kokubo, Takahiro Kanai, Michio Sato, Kazuaki Matsumura, Suong-Hyu Hyon, Munetaka Yokoyama, Joji Mochida and Hiroshi Nagashima

    Citation: BMC Biotechnology 2013 13:58

    Content type: Methodology article

    Published on:

  5. A key issue for safe and reproducible gene therapy approaches is the autologous and tissue-specific expression of transgenes. Tissue-specific expression in vivo is either achieved by transfer vectors that deli...

    Authors: Rudolf Haase, Terese Magnusson, Baowei Su, Florian Kopp, Ernst Wagner, Hans Lipps, Armin Baiker and Manfred Ogris

    Citation: BMC Biotechnology 2013 13:49

    Content type: Research article

    Published on:

  6. There is an increasing need to understand cell-cell interactions for cell and tissue engineering purposes, such as optimizing cell sheet constructs, as well as for examining adhesion defect diseases. For cell-...

    Authors: Qi Wei, Daniel Reidler, Min Ye Shen and Hayden Huang

    Citation: BMC Biotechnology 2013 13:17

    Content type: Research article

    Published on:

  7. Guanylate binding protein-1 (GBP-1) is a large GTPase which is actively secreted by endothelial cells. It is a marker and intracellular inhibitor of endothelial cell proliferation, migration, and invasion. We ...

    Authors: Oliver Bleiziffer, Matthias Hammon, Andreas Arkudas, Christian D Taeger, Justus P Beier, Kerstin Amann, Elisabeth Naschberger, Michael Stürzl, Raymund E Horch and Ulrich Kneser

    Citation: BMC Biotechnology 2012 12:94

    Content type: Research article

    Published on:

  8. Despite positive reports on the efficacy of stem cell therapy for the treatment of cardiovascular disease, the nature of stem cell homing to ischemic tissues remains elusive.

    Authors: Bert R Everaert, Irene Bergwerf, Nathalie De Vocht, Peter Ponsaerts, Annemie Van Der Linden, Jean-Pierre Timmermans and Christiaan J Vrints

    Citation: BMC Biotechnology 2012 12:93

    Content type: Research article

    Published on:

  9. Induced pluripotent stem (iPS) cells can differentiate into any cell type, which makes them an attractive resource in fields such as regenerative medicine, drug screening, or in vitro toxicology. The most importa...

    Authors: Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Rie Ouchi, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa and Hideki Taniguchi

    Citation: BMC Biotechnology 2012 12:81

    Content type: Methodology article

    Published on:

  10. In modern biotechnology, there is a need for pausing cell lines by cold storage to adapt large-scale cell cultures to the variable demand for their products. We compared various cell culture media/solutions fo...

    Authors: Gesine Pless-Petig, Martin Metzenmacher, Tobias R Türk and Ursula Rauen

    Citation: BMC Biotechnology 2012 12:73

    Content type: Research article

    Published on:

  11. Integrin-mediated interaction of neuronal cells with extracellular matrix (ECM) is important for the control of cell adhesion, morphology, motility, and differentiation in both in vitro and in vivo systems. Arg-G...

    Authors: Won Bae Jeon, Bo Hyung Park, Seong Kyoon Choi, Kyeong-Min Lee and Jin-Kyu Park

    Citation: BMC Biotechnology 2012 12:61

    Content type: Research article

    Published on:

  12. Achieving efficient introduction of plasmid DNA into primary cultures of mammalian cells is a common problem in biomedical research. Human primary cranial suture cells are derived from the connective mesenchym...

    Authors: Prem P Dwivedi, Peter J Anderson and Barry C Powell

    Citation: BMC Biotechnology 2012 12:45

    Content type: Methodology article

    Published on:

  13. Diabetes mellitus is a complicated disease with a pathophysiology that includes hyperinsulinemia, hyperglycemia and other metabolic impairments leading to many clinical complications. It is necessary to develo...

    Authors: Mina Rasouli, Zalinah Ahmad, Abdul Rahman Omar and Zeenathul N Allaudin

    Citation: BMC Biotechnology 2011 11:99

    Content type: Research article

    Published on:

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ISSN: 1472-6750

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