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Section edited by Joaquim Cabral
This section will consider articles that relate to stem cell research and regenerative medicine as well as cell culture methods and bioproduction in animal cells.
Research article
Umbilical cord blood provides a source of hematopoietic stem cells for transplantation with immunological and availability advantages over conventional bone marrow sources. Limited cell numbers and slower engr...
BMC Biotechnology 2017 17:65
Published on: 4 August 2017
Methodology article
Three-dimensional (3D) spheroids are frequently used in toxicological study because their morphology and function closely resemble those of tissue. As these properties are maintained over a long term, repeated...
BMC Biotechnology 2017 17:54
Published on: 20 June 2017
Research article
Ultrasound and microbubbles (USMB) have been shown to enhance the intracellular uptake of molecules, generally thought to occur as a result of sonoporation. The underlying mechanism associated with USMB-enhanc...
BMC Biotechnology 2017 17:45
Published on: 18 May 2017
Research article
Polysialic acid (polySia) is a carbohydrate modification of the neural cell adhesion molecule (NCAM), which is implicated in neural differentiation and plays an important role in tumor development and metastas...
BMC Biotechnology 2017 17:42
Published on: 12 May 2017
Research article
Recombinant factor VIII (FVIII), used for haemophilia A therapy, is one of the most challenging among the therapeutic proteins produced in heterologous expression systems. Deletion variant of FVIII, in which t...
BMC Biotechnology 2017 17:33
Published on: 24 March 2017
Research article
Producing transgenic chickens with chicken blastodermal cells (cBCs) is inefficient due to the extremely low germline transmission capacity of cBCs. As chicken primordial germ cells (PGCs) have been reported a...
BMC Biotechnology 2017 17:17
Published on: 20 February 2017
Research article
Because of the increasing number of diabetic patients, it is important to generate pancreatic and duodenal homeobox gene 1 (Pdx1)-expressing cells, which are capable of differentiating into pancreatic endocrin...
BMC Biotechnology 2017 17:14
Published on: 15 February 2017
Methodology article
Decellularization of tendon tissue plays a pivotal role in current tissue engineering approaches for in vitro research as well as for translation of graft-based tendon restoration into clinics. Automation of e...
BMC Biotechnology 2017 17:13
Published on: 14 February 2017
Research article
Traditional approaches for generating goat pluripotent stem cells (iPSCs) suffer from complexity and low preparation efficiency. Therefore, we tried to derive goat iPSCs with a new method by transfecting exoge...
BMC Biotechnology 2017 17:11
Published on: 13 February 2017
Research article
The human body has an extensive capacity to regenerate bone tissue after trauma. However large defects such as long bone fractures of the lower limbs cannot be restored without intervention and often lead to n...
BMC Biotechnology 2016 16:89
Published on: 12 December 2016
Research article
To achieve synthetic control over how a cell responds to other cells or the extracellular environment, it is important to reliably engineer proteins that can traffic and span the plasma membrane. Using a modul...
BMC Biotechnology 2016 16:88
Published on: 9 December 2016
Research article
The incapacity of articular cartilage (AC) for self-repair after damage ultimately leads to the development of osteoarthritis. Stem cell-based therapy has been proposed for the treatment of osteoarthritis (OA)...
BMC Biotechnology 2016 16:78
Published on: 9 November 2016
Research article
Tissue engineering and bone substitutes are subjects of intensive ongoing research. If the healing of bone fractures is delayed, osteoinductive materials that induce mesenchymal stem cells (MSCs) to form bone ...
BMC Biotechnology 2016 16:44
Published on: 20 May 2016
Research article
Fetal bovine serum (FBS) contains a wide range of growth factors, hormones, vitamins, amino acids, fatty acids and trace elements required for cell growth. It was shown that animal sera contain also extracellu...
BMC Biotechnology 2016 16:32
Published on: 2 April 2016
Research article
von Willebrand factor (VWF) is a key load bearing domain for mamalian cell adhesion by binding various macromolecular ligands in extracellular matrix such as, collagens, elastin, and glycosaminoglycans. Intere...
BMC Biotechnology 2016 16:16
Published on: 16 February 2016
Research article
Mesenchymal stem cells (MSCs) are viewed as a having significant potential for tissue engineering and regenerative medicine therapies. Clinical implementation of MSCs, however, demands that their preparation b...
BMC Biotechnology 2016 16:10
Published on: 1 February 2016
Research article
Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell line subc...
BMC Biotechnology 2016 16:6
Published on: 22 January 2016
Research article
We aimed to demonstrate that DF stem cells from impacted molars and canines can be used to improve bone regeneration on titanium implants surfaces. This study highlights the presence of stem cells in DF, their...
BMC Biotechnology 2015 15:114
Published on: 30 December 2015
Research article
Mesenchymal stem cells (MSCs) are of great interest in bone regenerative medicine due to their osteogenic potential and trophic effects. However, challenges to large-scale production of MSCs can hinder the tra...
BMC Biotechnology 2015 15:102
Published on: 31 October 2015
Research article
Chinese hamster ovary (CHO) cells have become the host of choice for the production of recombinant proteins, due to their capacity for correct protein folding, assembly, and posttranslational modifications. Th...
BMC Biotechnology 2015 15:98
Published on: 23 October 2015
