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BMC Biotechnology

Applied immunology

Section edited by Marko Radic

This section will consider studies on protein or cell engineering as they apply to the functions of the immune system and have applications in diagnostics, therapy and biomedical research.


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  1. Content type: Research article

    α-Lactalbumin (a-LA), β-lactoglobulin (β-LG) and lactoferrin (LF) are of high nutritional value which have made ingredients of choice in the formulation of modern foods and beverages. There remains an urgent n...

    Authors: Zhoumin Li, Fang Wen, Zhonghui Li, Nan Zheng, Jindou Jiang and Danke Xu

    Citation: BMC Biotechnology 2017 17:72

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  2. Content type: Methodology article

    The T-cell receptor (TCR), located on the surface of T cells, is responsible for the recognition of the antigen-major histocompatibility complex, leading to the initiation of an inflammatory response. Analysin...

    Authors: Elisa Rosati, C Marie Dowds, Evaggelia Liaskou, Eva Kristine Klemsdal Henriksen, Tom H Karlsen and Andre Franke

    Citation: BMC Biotechnology 2017 17:61

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  3. Content type: Research article

    The Gaussia princeps luciferase is used as a stand-alone reporter of transgene expression for in vitro and in vivo expression systems due to the rapid and easy monitoring of luciferase activity. We sought to simu...

    Authors: Michael Puckette, Thomas Burrage, John G. Neilan and Max Rasmussen

    Citation: BMC Biotechnology 2017 17:52

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  4. Content type: Research article

    Preclinical research implementing fluorescence-based approaches is inevitable for drug discovery and technology. For example, a variety of contrast agents developed for biomedical imaging are usually evaluated...

    Authors: Felista L. Tansi, Ronny Rüger, Ansgar M. Kollmeier, Claudia Böhm, Roland E. Kontermann, Ulf K. Teichgraeber, Alfred Fahr and Ingrid Hilger

    Citation: BMC Biotechnology 2017 17:8

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  5. Content type: Methodology article

    There is an ever-increasing need of monoclonal antibodies (mAbs) for biomedical applications and fully human binders are particularly desirable due to their reduced immunogenicity in patients. We have applied ...

    Authors: Laure-Hélène Ouisse, Laetitia Gautreau-Rolland, Marie-Claire Devilder, Michael Osborn, Melinda Moyon, Jonathan Visentin, Frank Halary, Marianne Bruggemann, Roland Buelow, Ignacio Anegon and Xavier Saulquin

    Citation: BMC Biotechnology 2017 17:3

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  6. Content type: Research article

    The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus. In this work we have de...

    Authors: Luciano Lucas Guerra, Natalia Inés Faccinetti, Aldana Trabucchi, Bruno David Rovitto, Adriana Victoria Sabljic, Edgardo Poskus, Ruben Francisco Iacono and Silvina Noemí Valdez

    Citation: BMC Biotechnology 2016 16:84

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  7. Content type: Methodology article

    Due to their rising incidence and progressive geographical spread, infections with mosquito-borne viruses, such as dengue (DENV), chikungunya and zika virus, have developed into major public health challenges....

    Authors: Natalie Rose, Carlos Augusto Pinho-Nascimento, Alessia Ruggieri, Paola Favuzza, Marco Tamborrini, Hanna Roth, Marcia Terezinha Baroni de Moraes, Hugues Matile, Thomas Jänisch, Gerd Pluschke and Katharina Röltgen

    Citation: BMC Biotechnology 2016 16:83

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  8. Content type: Research article

    The valuable role of immunotherapy in treating autoimmune diseases is increasingly recognized by those involved in the research and clinical application of new biopharmaceuticals products. However, many aspect...

    Authors: Gecilmara Salviato Pileggi, Aline Dayana Clemencio, Thiago Malardo, Sonir R Antonini, Vania Luiza Deperon Bonato, Wendy Martin Rios and Celio L Silva

    Citation: BMC Biotechnology 2016 16:40

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  9. Content type: Research article

    We previously developed in vitro immunization based on a fusion protein containing the transcriptional transactivator (Tat) of human immunodeficiency virus and a double domain, called ZZ, derived from protein A o...

    Authors: A. Wijkhuisen, A. Savatier, N. Cordeiro and M. Léonetti

    Citation: BMC Biotechnology 2016 16:22

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  10. Content type: Research article

    In an earlier study we developed a unique strategy allowing us to specifically eliminate antigen-specific murine B cells via their distinct B cell receptors using a new class of fusion proteins. In the present...

    Authors: Diana Klose, Ute Saunders, Stefan Barth, Rainer Fischer, Annett Marita Jacobi and Thomas Nachreiner

    Citation: BMC Biotechnology 2016 16:18

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  11. Content type: Methodology article

    The production of recombinant monoclonal antibodies in mammalian cell culture is of high priority in research and medical fields. A critical step in this process is the isolation of the antigen-binding domain ...

    Authors: Gaily Kivi, Kaupo Teesalu, Jüri Parik, Elen Kontkar, Mart Ustav Jr, Liis Noodla, Mart Ustav and Andres Männik

    Citation: BMC Biotechnology 2016 16:2

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  12. Content type: Research article

    Celiac disease (CD) is a chronic, small intestinal inflammatory disease mediated by dietary gluten and related prolamins. The only current therapeutic option is maintenance of a strict life-long gluten-free di...

    Authors: Valerie Stadlmann, Hanna Harant, Irina Korschineck, Marcela Hermann, Florian Forster and Albert Missbichler

    Citation: BMC Biotechnology 2015 15:109

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  13. Content type: Research article

    Low molecular weight haptens (<1000 Da) cannot be recognized by the immune system unless conjugated to larger carrier molecules. Antibodies to these exceptionally small antigens can still be generated with exq...

    Authors: Mohammed M. Al Qaraghuli, Soumya Palliyil, Gillian Broadbent, David C. Cullen, Keith A. Charlton and Andrew J. Porter

    Citation: BMC Biotechnology 2015 15:99

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  14. Content type: Research article

    Botulism is a naturally occurring disease, mainly caused by the ingestion of food contaminated by the botulinum neurotoxins (BoNTs). Botulinum neurotoxins are the most lethal. They are classified among the six...

    Authors: Arnaud Avril, Sebastian Miethe, Michel R. Popoff, Christelle Mazuet, Siham Chahboun, Christine Rasetti-Escargueil, Dorothea Sesardic, Philippe Thullier, Michael Hust and Thibaut Pelat

    Citation: BMC Biotechnology 2015 15:86

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  15. Content type: Research article

    Virus-like particles (VLPs) can be efficiently produced by heterologous expression of viral structural proteins in yeast. Due to their repetitive structure, VLPs are extensively used for protein engineering an...

    Authors: Milda Pleckaityte, Corinna M. Bremer, Alma Gedvilaite, Indre Kucinskaite-Kodze, Dieter Glebe and Aurelija Zvirbliene

    Citation: BMC Biotechnology 2015 15:85

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  16. Content type: Research article

    Within the last decade Virus-Like Particles (VLPs) have increasingly received attention from scientists for their use as a carrier of (peptide) molecules or as scaffold to present epitopes for use in subunit v...

    Authors: Afshin Hassani-Mehraban, Sjoerd Creutzburg, Luc van Heereveld and Richard Kormelink

    Citation: BMC Biotechnology 2015 15:80

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  17. Content type: Research article

    A novel influenza virus, subtype H7N9, circulated through China in 2013–2014. Its higher rates of human infection in a wide range of locations within China and the associated increased likelihood of human-to-h...

    Authors: Li Song, Dan Xiong, Xilong Kang, Yun Yang, Jing Wang, Yaxin Guo, Hui Xu, Sujuan Chen, Daxin Peng, Zhiming Pan and Xinan Jiao

    Citation: BMC Biotechnology 2015 15:79

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  18. Content type: Research article

    To extend the potency of vaccines against infectious diseases, vaccines should be able to exploit multiple arms of the immune system. One component of the immune system that is under-used in vaccine design is ...

    Authors: Kaila M. Bennett, Ronald D. Gorham Jr, Veronica Gusti, Lien Trinh, Dimitrios Morikis and David D. Lo

    Citation: BMC Biotechnology 2015 15:71

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  19. Content type: Research article

    Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsib...

    Authors: Juozas Nainys, Rita Lasickiene, Rasa Petraityte-Burneikiene, Jonas Dabrisius, Raimundas Lelesius, Vilimas Sereika, Aurelija Zvirbliene, Kestutis Sasnauskas and Alma Gedvilaite

    Citation: BMC Biotechnology 2014 14:100

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  20. Content type: Research article

    Prostate cancer is the most-diagnosed non-skin cancer among males in the US, and the second leading cause of cancer-related death. Current methods of treatment and diagnosis are not specific for the disease. T...

    Authors: Ryan M Williams, Cyrus J Hajiran, Sara Nayeem and Letha J Sooter

    Citation: BMC Biotechnology 2014 14:81

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