Fig. 2

2-dimensional view of the dimer interface of EPOR (amino acid side chain residue stereo view). Chains A and B are shown in first two panels, respectively interacting with EPO. The major clusters of hydrophobic residues in the dimer interface are shown as semicircles with median directed at amino acids/region interacting from other partners. The residues of interchain salt bridges and hydrogen bonds, as determined by DIMPLOT in LIGPLOT, are shown as dashed connections shown as stick models. A EPOR (ChainA)-EPO with key EPOR residues highlighted by circles. B EPOR (ChainB)-EPO with key EPOR residues highlighted by circles. C EPOR monomer interacting with an antagonist