Fig. 1

3-dimensional visual protein surface representations of the contact interfaces. A One view of the complex showing dimerized native structure of the extracellular domain of erythropoietin receptor (EPOR) in green and blue color in the presence of EPO (Purple color). Model shows interlocked surfaces between both the subunits of EPOR at different sites of EPO hormone (PDB ID 1CN4; https://doi.org/10.2210/pdb1CN4/pdb). B Another view of the EPOR monomer stabilized by the allosteric antagonist (PDB ID 1ERN; https://doi.org/10.2210/pdb1ERN/pdb). The two amino acids most critical for both the interactions are Ser91 and His153 of EPOR which are masked by the inhibitor impeding dimerization