Table 4 The fitting table of various indicators
Response | Model | Source | Sum of squares | df | Mean square | F-value | p-value | |
|---|---|---|---|---|---|---|---|---|
Drug loading | Linear model | Model | 145.66 | 2 | 72.83 | 34.11 | < 0.0001 | Significant |
Linear mixture | 145.66 | 2 | 72.83 | 34.11 | < 0.0001 | |||
Residual | 27.76 | 13 | 2.14 | |||||
Lack of fit | 14.83 | 8 | 1.85 | 0.72 | 0.6789 | Not significant | ||
Pure error | 12.93 | 5 | 2.59 | |||||
Cor total | 173.42 | 15 | ||||||
Solustion | Linear model | Model | 1.38 | 5 | 0.28 | 5.10 | 0.0139 | Significant |
Linear Mixture | 0.84 | 2 | 0.42 | 7.81 | 0.0091 | |||
AB | 0.16 | 1 | 0.16 | 2.94 | 0.1170 | |||
AC | 0.37 | 1 | 0.37 | 6.93 | 0.0250 | |||
BC | 0.33 | 1 | 0.33 | 6.12 | 0.0329 | |||
Residual | 0.54 | 10 | 0.054 | |||||
Lack of fit | 0.26 | 5 | 0.051 | 0.90 | 0.5460 | Not significant | ||
Pure error | 0.28 | 5 | 0.057 | |||||
Cor total | 1.92 | 15 | ||||||
Time | Quadratic model | Model | 4.931E + 05 | 5 | 98,626.17 | 7.62 | 0.0034 | Significant |
Linear Mixture | 93,897.03 | 2 | 46,948.52 | 3.63 | 0.0654 | |||
AB | 3.714E + 05 | 1 | 3.714E + 05 | 28.69 | 0.0003 | |||
AC | 3293.05 | 1 | 3293.05 | 0.2544 | 0.6249 | |||
BC | 1448.40 | 1 | 1448.40 | 0.1119 | 0.7449 | |||
Residual | 1.294E + 05 | 10 | 12,943.19 | |||||
Lack of fit | 76,315.64 | 5 | 15,263.13 | 1.44 | 0.3503 | Not significant | ||
Pure error | 53,116.25 | 5 | 10,623.25 | |||||
Cor total | 6.226E + 05 | 15 |