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Table 6 Literature review on DoE-based optimization of E. coli culture condition

From: Media optimization for SHuffle T7 Escherichia coli expressing SUMO-Lispro proinsulin by response surface methodology

Host Organism

Product

Design

Studied factors

Product increase

Reference

E. coli SHuffle T7

Biomass (SU-INS)

PBD, CCD

C, N sources, inorganic salts, pH

2.3X (shake flask), 5.9X (fermentor)

Present study

E. coli BL21 (DE3)

Phytase

CCD

C, N sources, salt

1.2X

[18]

E. coli (ATCC no. 11303)

L-Asparaginase

OFAT, CCD

C, N sources, ions, inoculum age and size

10X

[19]

E. coli BL21 (DE3)

L-Asparaginase II

FFD, CCFD

C, N sources, ions

NA

[20]

E. coli BL21 (DE3)

Streptokinase

PBD, CCD

C, N sources, ions

7X

[21]

E. coli

Dihydrolipohyl Dehydrogenase

CCFD

C, N sources, inorganic salts, pH

1.2X (shake flask), 1.7X (fermentor)

[22]

E. coli DH5α

Rheumatoid arthritis DNA vaccine

OFAT, PBD, BBD

C, N sources, salts, trace elements, pH, inoculum size, temperature

51.9%

[23]

E. coli MET-3

L-Methionine

PBD, BBD

C, N sources, salts

1.5X (shake flask), 6.4X (fermentor)

[24]

E. coli BL21 (DE3)

Reteplase

BBD

Temperature, Agitation, pH

2X

[25]

E. coli Δwaaf

Colanic acid

FFD, CCD

C, N sources, inorganic salts

12X

[26]

E. coli BL21 (DE3)

γ-cyclodextrin glycosyltransferase

OFAT, PBD, Steepest ascent path, BBD

C, N sources, inorganic salts, pH

2.83X

[27]