Table 4 Cost of nitrogen source and medium required for the production of nattokinase
Nitrogen source | Culture mode | Maximum nattokinase activity | References | Nitrogen source cost (Ton/dollar) | Medium cost (Ton/dollar) |
|---|---|---|---|---|---|
10 g/L yeast extract | 200 mL flask | 12.34 FU/mL | Wang et al. [29] | 30–35 | 31.97–39.02 |
13 g/L soy peptone | 250 mL flask | 31.06 ± 0.297 FU/mL | Nguyen [30] | 52.22–63.41 | 64.6–81.25 |
20 g/L soy peptone | 100 mL flask | 871.56 IU/mL | Zhou et al. [31] | 80.33–97.55 | 90.71–117.13 |
10 g/L peptone + 5 g/L yeast extract | 250 mL flask | 3284 ± 58 IU/mL | Ju et al. [32] | 55.16–66.27 | 78.10–89.21 |
55 g/L peptone | 250 mL flask | 3194.25 U/mL | Deepak et al. [33] | 275.31–314.64 | 281.8–326.17 |
100%TPW | 500-mL flask | 7708.89 ± 133.67 IU/mL | In study | – | 19–37.92 |