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Fig. 1 | BMC Biotechnology

Fig. 1

From: Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

Fig. 1

Engineering and optimization of early hCO shape-confinement in agarose microwells. a Schematic description of the agarose microwell fabrication (see also Methods for details). b Volume change of EBs seeded in a commercial 96-well plate. n = 20 EBs per time point. Error bars = 95% confidence intervals. c Size comparison of day 10 hCOs. n = 50 hCOs per shape. Error bars = 95% confidence intervals. d Development of EBs in distinctly shaped agarose microwells and 96-wells. e Images showing the shape retention of EBs. f Later developmental points of hCOs that were derived from EBs in microwells and 96-well plates. g Schematic of the experimental timeline

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