Table 1 Proteins DE at both day 6 and 10 between high and low peak VCD CDCLs or between normal and extended culture VCD CDCLs.

Gene

Accession

Description

D6 Fold change

D6 Phenotype

D10 Fold change

D10 Phenotype

MCM2

G3H7V9

DNA helicase

2.56

Up in high peak VCD

2.63

Up in high peak VCD

XPO7

G3GUX2

Exportin-7 (Fragment)

2.43

Up in high peak VCD

2.06

Up in high peak VCD

EPHA2

G3I863

Ephrin type-A receptor 2

2.37

Up in high peak VCD

1.63

Up in high peak VCD

SMC4

G3IAU0

Uncharacterized protein (Fragment)

2.28

Up in high peak VCD

2.73

Up in high peak VCD

PGM2

G3IFE7

Phosphoglucomutase-2

2.14

Up in high peak VCD

1.53

Up in high peak VCD

PDE12

G3GUS6

2′,5′-phosphodiesterase 12

2.09

Up in high peak VCD

1.73

Up in high peak VCD

SEPSECS

G3I841

O-phosphoseryl-tRNA (Sec) selenium transferase

2.05

Up in high peak VCD

1.66

Up in high peak VCD

TRIP13

G3ILQ1

Thyroid receptor-interacting protein 13

2.00

Up in high peak VCD

2.59

Up in high peak VCD

NCAPD2

G3GUM5

Condensin complex subunit 1

1.89

Up in high peak VCD

4.88

Up in high peak VCD

SF3B3

G3HAF4

Splicing factor 3B subunit 3

1.85

Up in high peak VCD

1.56

Up in high peak VCD

NCAPG

G3HR05

Condensin complex subunit 3

1.85

Up in high peak VCD

5.07

Up in high peak VCD

IPO4

G3HDD8

Importin-4

1.78

Up in high peak VCD

1.50

Up in high peak VCD

CDK1

G3HVL1

Cell division control protein 2-like

1.70

Up in high peak VCD

1.74

Up in high peak VCD

MCM5

G3IAI5

DNA helicase

1.67

Up in high peak VCD

2.59

Up in high peak VCD

RCC2

G3IJB6

Protein RCC2

1.66

Up in high peak VCD

2.08

Up in high peak VCD

ECM29

G3I5Z8

Proteasome-associated protein ECM29-like

1.64

Up in high peak VCD

1.51

Up in high peak VCD

PRPF6

G3IBT1

Pre-mRNA-processing factor 6

1.62

Up in high peak VCD

1.50

Up in high peak VCD

PRMT5

G3HRD3

Protein arginine N-methyltransferase 5

1.58

Up in high peak VCD

1.58

Up in high peak VCD

ELOVL7

G3GV15

Elongation of very long chain fatty acids protein 7

5.09

Up in low peak VCD

4.91

Up in low peak VCD

PC

G3I4L6

Pyruvate carboxylase

2.68

Up in low peak VCD

1.87

Up in low peak VCD

HMOX1

G3IAI6

Heme oxygenase

2.40

Up in low peak VCD

2.53

Up in low peak VCD

AOC3

G3I525

Amine oxidase (Fragment)

2.36

Up in low peak VCD

3.52

Up in low peak VCD

FLOT1

G3HQP7

Flotillin-1

2.15

Up in low peak VCD

1.51

Up in low peak VCD

XDH

G3I4G1

Xanthine dehydrogenase/oxidase

2.02

Up in low peak VCD

1.84

Up in low peak VCD

PSMC6

G3I6I1

26S protease regulatory subunit S10B

2.00

Up in low peak VCD

1.63

Up in low peak VCD

SQOR

G3HMD2

Sulfide:quinone oxidoreductase, mitochondrial

1.96

Up in low peak VCD

1.81

Up in low peak VCD

GPD1L

G3GV81

Glycerol-3-phosphate dehydrogenase [NAD(+)]

1.89

Up in low peak VCD

1.63

Up in low peak VCD

ACO1

G3HQZ8

Cytoplasmic aconitate hydratase

1.78

Up in low peak VCD

1.77

Up in low peak VCD

PARP3

G3H896

Poly [ADP-ribose] polymerase

1.77

Up in low peak VCD

1.82

Up in low peak VCD

VPS13C

G3H509

Vacuolar protein sorting-associated protein 13C

1.62

Up in low peak VCD

2.74

Up in low peak VCD

UBR4

G3I905

E3 ubiquitin-protein ligase UBR4

1.60

Up in low peak VCD

1.63

Up in low peak VCD

MYO18A

G3I7W5

Myosin-XVIIIa

1.60

Up in low peak VCD

1.99

Up in low peak VCD

CCT2

G3HZ42

T-complex protein 1 subunit beta

1.55

Up in low peak VCD

2.26

Up in low peak VCD

ACSF2

G3HBE7

Acyl-CoA synthetase family member 2, mitochondrial

1.55

Up in low peak VCD

1.82

Up in low peak VCD

MYO6

G3I0Q8

Myosin-VI

1.53

Up in low peak VCD

2.06

Up in low peak VCD

HACD3

G3HUX9

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

1.51

Up in low peak VCD

1.52

Up in low peak VCD

Gene

Accession

Description

D6 Fold change

D6 Phenotype

D10 Fold change

D10 Phenotype

FLNC

G3GZ94

Filamin-C

Infinity

Up in extended VCD

2.520228255

Up in extended VCD

CAND1

G3GY17

Cullin-associated NEDD8-dissociated protein 1

1.86816535

Up in extended VCD

1.840673521

Up in extended VCD

GBF1

G3HXV9

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1.7337689

Up in extended VCD

1.587167296

Up in extended VCD

THBS1

G3HHV4

Thrombospondin-1

6.13878563

Up in Normal VCD

51.1241988

Up in Normal VCD

AOC3

G3I525

Amine oxidase (Fragment)

2.28761761

Up in Normal VCD

2.430711805

Up in Normal VCD

HEXB

G3HXN7

Beta-hexosaminidase

2.24732962

Up in Normal VCD

2.440308152

Up in Normal VCD

DNM2

G3H6B2

Dynamin

2.01883385

Up in Normal VCD

1.537175512

Up in Normal VCD

TRPV2

G3GVL1

Transient receptor potential cation channel subfamily V member 2

2.01058317

Up in Normal VCD

1.877033504

Up in Normal VCD

NEK7

G3HM24

Serine/threonine-protein kinase Nek7

1.81795951

Up in Normal VCD

1.717212511

Up in Normal VCD

PICALM

G3HXR8

Phosphatidylinositol-binding clathrin assembly protein

1.80428032

Up in Normal VCD

1.615700185

Up in Normal VCD

GPD2

G3HT22

Glycerol-3-phosphate dehydrogenase

1.76165957

Up in Normal VCD

1.684923387

Up in Normal VCD

MYO18A

G3I7W5

Myosin-XVIIIa

1.73531125

Up in Normal VCD

2.435810461

Up in Normal VCD

TRAP1

G3I027

Heat shock protein 75 kDa, mitochondrial

1.69466205

Up in Normal VCD

4.665085424

Up in Normal VCD

EHD1

G3I6F9

EH domain-containing protein 1

1.65572091

Up in Normal VCD

3.187918972

Up in Normal VCD

PXDN

G3HBI1

Peroxidasin-like

1.55976418

Up in Normal VCD

2.637755938

Up in Normal VCD

Up in Normal VCD