Table 1 Pharmacokinetic parameters in mice calculated with WinNonLin
From: Development and biological activity of long-acting recombinant human interferon-α2b
Treatment | Dose (μg/kg) | T1/2 (h) | Tmax (h) | Cmax (ng/ml) | AUC (ng h/ml) |
|---|---|---|---|---|---|
IFN-1CTPON | 50 | 2.62 ± 0.34 | 1.63 ± 0.52 | 13.91 ± 4.47 | 59.21 ± 21.01 |
IFN-2CTPON | 50 | 3.45 ± 0.87 | 2 ± 0 | 23.9 ± 5.6 | 254.67 ± 69.58 |
rhIFN-α2b | 50 | 1.34 ± 0.48 | 0.69 ± 0.26 | 14.03 ± 2.68 | 39.87 ± 11.9 |