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Table 1 Pharmacokinetic parameters in mice calculated with WinNonLin

From: Development and biological activity of long-acting recombinant human interferon-α2b

TreatmentDose
(μg/kg)
T1/2
(h)
Tmax
(h)
Cmax
(ng/ml)
AUC
(ng h/ml)
IFN-1CTPON502.62 ± 0.341.63 ± 0.5213.91 ± 4.4759.21 ± 21.01
IFN-2CTPON503.45 ± 0.872 ± 023.9 ± 5.6254.67 ± 69.58
rhIFN-α2b501.34 ± 0.480.69 ± 0.2614.03 ± 2.6839.87 ± 11.9