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Fig. 2 | BMC Biotechnology

Fig. 2

From: Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity

Fig. 2

Molecular characterization of the CDR3 belonging to the selected anti-EBOV VP35 scFvs. a Schematic representation of the scFv gene in the phage display cassette showing the position of the variable CDR3 in the VH and VL chains. Lac p: Lac promoter; PelB: peptide leader for secretion in the bacterial periplasm. b Sequences of the DP47 VH gene and DPL16 VL gene are shown. CDR1, CDR2, CDR3, identified through IMGT (international ImMunoGeneTics information system)/V-Quest analysis are underlined. c Amino acid composition of the CDR3 regions in the VH and VL domains of the five most reactive anti-VP35 scFvs

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