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Table 3 Anticoagulant activity and molecular weight of LMWH

From: Structure-based engineering of heparinase I with improved specific activity for degrading heparin

Sample

Anti-FXa(IU/mg)

Anti-FIIa(IU/mg)

Anti-FXa/Anti-IIa

Relative molecular mass

1

121.72 ± 4.18

48.37 ± 5.02

2.5164 ± 0.15

4326.984

2

112.18 ± 9.32

59.01 ± 3.21

1.9010 ± 0.06

5168.031

3

113.24 ± 7.51

56.35 ± 6.08

2.0096 ± 0.13

4944.875

4

115.72 ± 3.29

58.92 ± 3.72

1.9640 ± 0.09

5209.882

5

119.89 ± 2.87

57.05 ± 3.02

2.1015 ± 0.12

5032.487

  1. 1:Low molecular weight heparin, 2:Heparin degraded by wild-type Ph-hepI,3:Heparin degraded by mutant S169D,4:Heparin degraded by mutant A259D, 5:Heparin degraded by mutant S169D/A259D