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Fig. 3 | BMC Biotechnology

Fig. 3

From: Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction

Fig. 3

Comparison of the potency of NicA2A107R to wt NicA2 in lowering blood and brain nicotine levels in vivo. Effect of wt NicA2 or NicA2A107R treatment (0.625 mg/kg dosed i.v.) on (a) blood and (b) brain nicotine levels 3 min after 0.03 mg/kg nicotine (i.v; N = 8 rats per group). Percent remaining compared to controls are noted above each column. Control group was dosed with BSA. Mean nicotine levels ±SD. Differences between wt NicA2 and NicA2107R were significant: **** p < 0.0001, * p < 0.05. Dashed line is LOQ: 2 ng/mL for blood, 2 ng/g for brain

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