Fig. 1
From: Crosslinked flagella as a stabilized vaccine adjuvant scaffold
Introducing intermolecular disulfide bonds in FliC protofilaments. (Left) Depiction of the helical translations and proposed locations to introduce disulfide bonds between neighboring flagellin protofilaments. Domains N’D0 and N’D1 are colored dark and light blue respectively while C’D0 and C’D1 are orange and red, respectively. (Right) Molecular graphic representation of sites of interest within neighboring protofilament monomers. Insets show a zoomed and rotated view of the amino acid interactions with the specific distances shown: 1) Glu454[Oε1] – Asn5[Nδ1], 2) Asn430[Oδ1] – Asn38[Nδ1], and 3) Gln97[N] – Gln62[Oε1], Gln97[Nε2] – Gln62[Oε1]