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Fig. 5 | BMC Biotechnology

Fig. 5

From: Novel anti-CD38 humanized mAb SG003 possessed enhanced cytotoxicity in lymphoma than Daratumumab via antibody-dependent cell-mediated cytotoxicity

Fig. 5

The epitope of SG003 was different from Daratumumab. a theoretical structure of the extracellular domain of CD38 and SG003 complex, according to which the potential epitope of SG003 located in 76E78R79H107Q111K114T115Q116T117V194R195R198E233E234K in CD38; b CD38 and its four mutations. The indicated sites were replaced with alanine; c Flow cytometry analysis of SG003 to bind CD38 mutations. The replacement of residues 76–79, 107–117, 194–198, or 233–234 induced the failure of SG003 to recognize CD38, while the epitope of Daratumumab were 233–246 and 267–280 of CD38

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