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Table 1 Predicted solubilities of recombinant human erythropoietin. Solubility profile was defined as described in Chan et al. [29]. Positive patch sizes are divided by that best separating soluble and insoluble datasets [33], above 1.0 implies predicted insolubility

From: Surface patches on recombinant erythropoietin predict protein solubility: engineering proteins to minimise aggregation

Protein Pos patch ratio to threshold Prediction
rHuEPO wild-type 1.49 Insoluble
rHuEPO F48D 0.75 Soluble
rHuEPO R150D 0.61 Soluble
rHuEPO F48D/R150D 0.47 Soluble
rHuEPO E13K 2.47 Insoluble