Treatment | SD100 | SD100 pacrA | SD100 pKan | SD100 pacrB | SD100 pSpec | |
Amp | IC50 | 955.2 ± 256 | 1315 ± 77 (ns) | 1151 ± 82 (ns) | 1109 ± 123 (ns) | 658.6 ± 88.3 |
% diff from SD100 | 0% | 27% | 20% | 16% | −31% | |
Cm | IC50 | 2.290 ± 0.401 | 1.444 ± 0.114 | 1.390 ± 0.186 | 1.976 ± 0.734 (ns) | 1.653 ± 0.205 (ns) |
% diff from SD100 | 0% | −59% | −39% | −14% | −28% | |
Ery | IC50 | 0.358 ± 0.081 μg/mL | 0.080 ± 0.003 | 0.072 ± 0.007 | 0.138 ± 0.080 (ns) | 0.079 ± 0.005 |
% diff from SD100 | 0% | −77% | − 79% | −61% | −78% | |
Treatment | SD277 | SD277 pacrA | SD277 pKan | SD277 pacrB | SD277 pSpec | |
Amp | IC50 | 1570 ± 170 μg/mL | 1117 ± 21 μg/mL | 76.67 ± 28.5 μg/mL | 118.2 ± 8.7 μg/mL | 412.6 ± 34.8 μg/mL |
% diff from SD277 | 0% | −29% | −95% | −92% | −74% | |
Cm | IC50 | 4.749 ± 1.043 μg/mL | 1.833 ± 0.390 μg/mL | 1.793 ± 0.430 μg/mL | 1.984 ± 0.527 μg/mL | 2.96 ± 0.4 μg/mL |
% diff from SD277 | 0% | −61% | − 62% | −58% | −38% | |
Ery | IC50 | 0.427 ± 0.249 μg/mL | 0.091 ± 0.034 μg/mL | 0.149 ± 0.016 μg/mL | 0.080 ± 0.008 μg/mL | 0.055 ± 0.004 μg/mL |
% diff from SD277 | 0% | −79% | −65% | −81% | −87% |