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Table 2 Recombinant FIPs produced in Pichia pastoris

From: Recombinant Expression and Bioactivity Comparison of Four Typical Fungal Immunomodulatory Proteins from Three Main Ganoderma Species

FIPs Pichia strains Vectors Yields
(mg L− 1)
Bioactivities References
LZ-8 GS115 pPIC-9 191.2 hemagglutination, mitogenesis, IL-2 induction, anti-tumor Lin et al., 2009
GS115 pPIC-9 K 270 hemagglutination, mitogenesis Xue et al., 2008
X-33 pPICZαA 350 not mentioned Bastiaan et al., 2013
X-33 pPICZαA 34.4 hemagglutination Song et al., 2011
GS115 pPIC-9 253.6 hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor Current study
FIP-fve GS115 pPIC-9 158.2 hemagglutination, mitogenesis, IL-2 & IFN-γ induction Lin et al., 2013
X-33 pPICZαA 18.9 hemagglutination Bastiaan et al., 2013
FIP-vvo X-33 pPICZαA 410 hemagglutination, mitogenesis, IFN-γ induction Sun et al.,2014
FIP-nha X-33 pPICZαA 42.7 hemagglutination Bastiaan et al., 2013
FIP-cru GS115 pPIC-9 148.5 hemagglutination, mitogenesis, IL-2 induction Lin et al., 2016
LZ-9 X-33 pPICZαA 6.7 hemagglutination Bastiaan et al., 2013
FIP-gsi GS115 pPIC-9 264.3 hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor Current study
FIP-gap1 GS115 pPIC-9 247.4 hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor Current study
FIP-gap2 GS115 pPIC-9 197.5 hemagglutination, mitogenesis, IL-2& IFN-γ induction, anti-tumor Current study
  1. LZ-8, FIP-fve, FIP-vvo, FIP-nha, FIP-cru, LZ-9, FIP-gsi, FIP-gap1 and FIP-gap2 represent FIPs from G. lucidum, Flammulina velutipes, Volvariella volvacea, Nectria haematococca, Chroogomphis rutilus, G. lucidum, G. sinense and G. applanatum