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Fig. 7 | BMC Biotechnology

Fig. 7

From: The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

Fig. 7

Effects of NicA2 in rats receiving multiple nicotine doses. Rats were pretreated with either 10 mg/kg NicA2 or BSA i.v. Five minutes later two groups received a single nicotine dose of 0.03 mg/kg i.v. and two groups received 5 nicotine doses at 10 min intervals. Blood and brain concentrations were measured 3 min after nicotine dosing. Numbers above bars are the percent reduction of nicotine concentrations compared to BSA control, in blood (upper panel) and brain (lower panel). *** p < 0.001, two-tailed unpaired t tests with Welch’s correction. Mean ± SD, n = 10/group

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BMC Biotechnology

ISSN: 1472-6750

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