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Fig. 6 | BMC Biotechnology

Fig. 6

From: The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

Fig. 6

Reduction of blood and brain nicotine concentrations by NicA2. Rats were pretreated with NicA2 i.v. and 5 min later received nicotine 0.03 mg/kg i.v. Groups of rats had nicotine levels measured at 1, 3 or 5 min. Blood (upper panel) and brain (lower panel) nicotine concentrations were reduced by NicA2 in a dose- and time-related manner, with substantial NicA2 effects at doses of ≥5 mg/kg, and with greater reduction of nicotine concentrations at 3 and 5 min than at 1 min. **p < 0.01, ***p < 0.001 compared to BSA using Bonferroni-corrected Welch’s t tests. Mean ± SD, n = 8/group

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BMC Biotechnology

ISSN: 1472-6750

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