Fig. 5From: The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in ratsNicA2 and NicA2-ABD pharmacokinetics. Rats (n = 3/group) received either NicA2 or NicA2-ABD 5 mg/kg i.v. The terminal half-lives were determined by noncompartmental analysis. Data are the mean ± SD of individual analysesBack to article page