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Fig. 10 | BMC Biotechnology

Fig. 10

From: The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

Fig. 10

Effects of NicA2-ABD on NSA during unlimited access to nicotine. Mean (± SD) number of infusions during 23-h access following pretreatment with PBS vehicle (V) and NicA2-ABD over six consecutive test sessions, expressed as a percentage of baseline. Each point represents the mean of four rats. The dotted horizontal line represents baseline. The dashed horizontal line represents the 50% reduction criterion for extinction. Different from V, **p < 0.01, ***p < 0.001

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