TY - JOUR AU - Patel, M. M. AU - Patel, B. M. PY - 2017 DA - 2017// TI - Crossing the blood-brain barrier: recent advances in drug delivery to the brain JO - CNS Drugs VL - 31 UR - https://doi.org/10.1007/s40263-016-0405-9 DO - 10.1007/s40263-016-0405-9 ID - Patel2017 ER - TY - JOUR AU - Pardridge, W. M. PY - 2010 DA - 2010// TI - Biopharmaceutical drug targeting to the brain JO - J Drug Target VL - 18 UR - https://doi.org/10.3109/10611860903548354 DO - 10.3109/10611860903548354 ID - Pardridge2010 ER - TY - JOUR AU - Rossetto, O. AU - Scorzeto, M. AU - Megighian, A. AU - Montecucco, C. PY - 2013 DA - 2013// TI - Tetanus neurotoxin JO - Toxicon VL - 66 UR - https://doi.org/10.1016/j.toxicon.2012.12.027 DO - 10.1016/j.toxicon.2012.12.027 ID - Rossetto2013 ER - TY - JOUR AU - Deinhardt, K. AU - Salinas, S. AU - Verastegui, C. AU - Watson, R. AU - Worth, D. AU - Hanrahan, S. AU - Bucci, C. AU - Schiavo, G. PY - 2006 DA - 2006// TI - Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway JO - Neuron VL - 52 UR - https://doi.org/10.1016/j.neuron.2006.08.018 DO - 10.1016/j.neuron.2006.08.018 ID - Deinhardt2006 ER - TY - STD TI - Sozbilen MC, Ozturk M, Kaftan G, Dagci T, Ozyalcin H, Armagan G. Neuroprotective effects of C-terminal domain of tetanus toxin on rat brain against motorneuron damages after experimental spinal cord injury. Spine (Phila Pa 1976). 2017;43(6):E327-E333. ID - ref5 ER - TY - JOUR AU - Calvo, A. C. AU - Olivan, S. AU - Manzano, R. AU - Zaragoza, P. AU - Aguilera, J. AU - Osta, R. PY - 2012 DA - 2012// TI - Fragment C of tetanus toxin: new insights into its neuronal signaling pathway JO - Int J Mol Sci VL - 13 UR - https://doi.org/10.3390/ijms13066883 DO - 10.3390/ijms13066883 ID - Calvo2012 ER - TY - JOUR AU - Herrando-Grabulosa, M. AU - Casas, C. AU - Aguilera, J. PY - 2013 DA - 2013// TI - The C-terminal domain of tetanus toxin protects motoneurons against acute excitotoxic damage on spinal cord organotypic cultures JO - J Neurochem VL - 124 UR - https://doi.org/10.1111/jnc.12062 DO - 10.1111/jnc.12062 ID - Herrando-Grabulosa2013 ER - TY - JOUR AU - Gunay, H. AU - Kucuk, L. AU - Erbas, O. AU - Atamaz, F. C. AU - Kucuk, U. AU - Coskunol, E. PY - 2014 DA - 2014// TI - The effectiveness of tetanus toxin on sciatic nerve regeneration: a preliminary experimental study in rats JO - Microsurgery VL - 34 UR - https://doi.org/10.1002/micr.22249 DO - 10.1002/micr.22249 ID - Gunay2014 ER - TY - STD TI - Mendieta L, Granado N, Aguilera J, Tizabi Y, Moratalla R. Fragment C domain of tetanus toxin mitigates methamphetamine neurotoxicity and its motor consequences in mice. Int J Neuropsychopharmacol. 2016;19(8):pyw021. ID - ref9 ER - TY - JOUR AU - Hatok, J. AU - Racay, P. PY - 2016 DA - 2016// TI - Bcl-2 family proteins: master regulators of cell survival JO - Biomol Concepts VL - 7 UR - https://doi.org/10.1515/bmc-2016-0015 DO - 10.1515/bmc-2016-0015 ID - Hatok2016 ER - TY - JOUR AU - Watanabe, Y. AU - Kono, Y. AU - Nanba, E. AU - Ohama, E. AU - Nakashima, K. PY - 1997 DA - 1997// TI - Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis JO - FEBS Lett VL - 400 UR - https://doi.org/10.1016/S0014-5793(96)01362-2 DO - 10.1016/S0014-5793(96)01362-2 ID - Watanabe1997 ER - TY - JOUR AU - Herreros, J. AU - Lalli, G. AU - Schiavo, G. PY - 2000 DA - 2000// TI - C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor JO - Biochem J VL - 347 UR - https://doi.org/10.1042/bj3470199 DO - 10.1042/bj3470199 ID - Herreros2000 ER - TY - JOUR AU - Herreros, J. AU - Lalli, G. AU - Montecucco, C. AU - Schiavo, G. PY - 2000 DA - 2000// TI - Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons JO - J Neurochem VL - 74 UR - https://doi.org/10.1046/j.1471-4159.2000.0741941.x DO - 10.1046/j.1471-4159.2000.0741941.x ID - Herreros2000 ER - TY - JOUR AU - Gotz, R. AU - Karch, C. AU - Digby, M. R. AU - Troppmair, J. AU - Rapp, U. R. AU - Sendtner, M. PY - 2000 DA - 2000// TI - The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells JO - Hum Mol Genet VL - 9 UR - https://doi.org/10.1093/hmg/9.17.2479 DO - 10.1093/hmg/9.17.2479 ID - Gotz2000 ER - TY - JOUR AU - Lee, C. S. AU - Kim, Y. J. AU - Ko, H. H. AU - Han, E. S. PY - 2005 DA - 2005// TI - Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition JO - Biochem Pharmacol VL - 70 UR - https://doi.org/10.1016/j.bcp.2005.04.029 DO - 10.1016/j.bcp.2005.04.029 ID - Lee2005 ER - TY - JOUR AU - Adams, J. M. AU - Cory, S. PY - 1998 DA - 1998// TI - The Bcl-2 protein family: arbiters of cell survival JO - Science VL - 281 UR - https://doi.org/10.1126/science.281.5381.1322 DO - 10.1126/science.281.5381.1322 ID - Adams1998 ER - TY - JOUR AU - Kostic, V. AU - Jackson-Lewis, V. AU - de Bilbao, F. AU - Dubois-Dauphin, M. AU - Przedborski, S. PY - 1997 DA - 1997// TI - Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5325.559 DO - 10.1126/science.277.5325.559 ID - Kostic1997 ER - TY - JOUR AU - Azzouz, M. AU - Hottinger, A. AU - Paterna, J. C. AU - Zurn, A. D. AU - Aebischer, P. AU - Bueler, H. PY - 2000 DA - 2000// TI - Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2 JO - Hum Mol Genet VL - 9 UR - https://doi.org/10.1093/hmg/9.5.803 DO - 10.1093/hmg/9.5.803 ID - Azzouz2000 ER - TY - JOUR AU - Soane, L. AU - Fiskum, G. PY - 2005 DA - 2005// TI - Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins JO - J Bioenerg Biomembr VL - 37 UR - https://doi.org/10.1007/s10863-005-6590-8 DO - 10.1007/s10863-005-6590-8 ID - Soane2005 ER - TY - JOUR AU - Moreno-Igoa, M. AU - Calvo, A. C. AU - Penas, C. AU - Manzano, R. AU - Olivan, S. AU - Munoz, M. J. AU - Mancuso, R. AU - Zaragoza, P. AU - Aguilera, J. AU - Navarro, X. PY - 2010 DA - 2010// TI - Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy JO - J Mol Med (Berl) VL - 88 UR - https://doi.org/10.1007/s00109-009-0556-y DO - 10.1007/s00109-009-0556-y ID - Moreno-Igoa2010 ER - TY - JOUR AU - Chaib-Oukadour, I. AU - Gil, C. AU - Aguilera, J. PY - 2004 DA - 2004// TI - The C-terminal domain of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways JO - J Neurochem VL - 90 UR - https://doi.org/10.1111/j.1471-4159.2004.02586.x DO - 10.1111/j.1471-4159.2004.02586.x ID - Chaib-Oukadour2004 ER - TY - JOUR AU - Rummel, A. PY - 2017 DA - 2017// TI - Two feet on the membrane: uptake of Clostridial neurotoxins JO - Curr Top Microbiol Immunol VL - 406 ID - Rummel2017 ER - TY - JOUR AU - Arakawa, Y. AU - Sendtner, M. AU - Thoenen, H. PY - 1990 DA - 1990// TI - Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines JO - J Neurosci VL - 10 UR - https://doi.org/10.1523/JNEUROSCI.10-11-03507.1990 DO - 10.1523/JNEUROSCI.10-11-03507.1990 ID - Arakawa1990 ER - TY - JOUR PY - 1996 DA - 1996// TI - A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis JO - Neurology VL - 46 UR - https://doi.org/10.1212/WNL.46.5.1244 DO - 10.1212/WNL.46.5.1244 ID - ref24 ER - TY - JOUR AU - Miller, R. G. AU - Petajan, J. H. AU - Bryan, W. W. AU - Armon, C. AU - Barohn, R. J. AU - Goodpasture, J. C. AU - Hoagland, R. J. AU - Parry, G. J. AU - Ross, M. A. AU - Stromatt, S. C. PY - 1996 DA - 1996// TI - A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group JO - Ann Neurol VL - 39 UR - https://doi.org/10.1002/ana.410390215 DO - 10.1002/ana.410390215 ID - Miller1996 ER - TY - JOUR AU - Dobrenis, K. AU - Joseph, A. AU - Rattazzi, M. C. PY - 1992 DA - 1992// TI - Neuronal lysosomal enzyme replacement using fragment C of tetanus toxin JO - Proc Natl Acad Sci U S A VL - 89 UR - https://doi.org/10.1073/pnas.89.6.2297 DO - 10.1073/pnas.89.6.2297 ID - Dobrenis1992 ER - TY - JOUR AU - Francis, J. W. AU - Hosler, B. A. AU - Brown, R. H. AU - Fishman, P. S. PY - 1995 DA - 1995// TI - CuZn superoxide dismutase (SOD-1):tetanus toxin fragment C hybrid protein for targeted delivery of SOD-1 to neuronal cells JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.25.15434 DO - 10.1074/jbc.270.25.15434 ID - Francis1995 ER - TY - JOUR AU - Francis, J. W. AU - Ren, J. AU - Warren, L. AU - Brown, R. H. AU - Finklestein, S. P. PY - 1997 DA - 1997// TI - Postischemic infusion of Cu/Zn superoxide dismutase or SOD:Tet451 reduces cerebral infarction following focal ischemia/reperfusion in rats JO - Exp Neurol VL - 146 UR - https://doi.org/10.1006/exnr.1997.6547 DO - 10.1006/exnr.1997.6547 ID - Francis1997 ER - TY - JOUR AU - Chian, R. J. AU - Li, J. AU - Ay, I. AU - Celia, S. A. AU - Kashi, B. B. AU - Tamrazian, E. AU - Matthews, J. C. AU - Bronson, R. T. AU - Rossomando, A. AU - Pepinsky, R. B. PY - 2009 DA - 2009// TI - IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice JO - Brain Res VL - 1287 UR - https://doi.org/10.1016/j.brainres.2009.06.066 DO - 10.1016/j.brainres.2009.06.066 ID - Chian2009 ER - TY - JOUR AU - Ciriza, J. AU - Moreno-Igoa, M. AU - Calvo, A. C. AU - Yague, G. AU - Palacio, J. AU - Miana-Mena, F. J. AU - Munoz, M. J. AU - Zaragoza, P. AU - Brulet, P. AU - Osta, R. PY - 2008 DA - 2008// TI - A genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model JO - Restor Neurol Neurosci VL - 26 ID - Ciriza2008 ER - TY - JOUR AU - Kissa, K. AU - Mordelet, E. AU - Soudais, C. AU - Kremer, E. J. AU - Demeneix, B. A. AU - Brulet, P. AU - Coen, L. PY - 2002 DA - 2002// TI - In vivo neuronal tracing with GFP-TTC gene delivery JO - Mol Cell Neurosci VL - 20 UR - https://doi.org/10.1006/mcne.2002.1141 DO - 10.1006/mcne.2002.1141 ID - Kissa2002 ER - TY - JOUR AU - Miana-Mena, F. J. AU - Munoz, M. J. AU - Roux, S. AU - Ciriza, J. AU - Zaragoza, P. AU - Brulet, P. AU - Osta, R. PY - 2004 DA - 2004// TI - A non-viral vector for targeting gene therapy to motoneurons in the CNS JO - Neurodegener Dis VL - 1 UR - https://doi.org/10.1159/000080050 DO - 10.1159/000080050 ID - Miana-Mena2004 ER - TY - JOUR AU - Carlton, E. AU - Teng, Q. AU - Federici, T. AU - Yang, J. AU - Riley, J. AU - Boulis, N. M. PY - 2008 DA - 2008// TI - Fusion of the tetanus toxin C fragment binding domain and Bcl-xL for protection of peripheral nerve neurons JO - Neurosurgery VL - 63 UR - https://doi.org/10.1227/01.NEU.0000334415.45003.EA DO - 10.1227/01.NEU.0000334415.45003.EA ID - Carlton2008 ER -