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Fig. 3 | BMC Biotechnology

Fig. 3

From: Successful production of genome-edited rats by the rGONAD method

Fig. 3

Recovery of coat-color mutation in albino WKY rats using KI approach. a Scheme diagram of the recovery of coat-color mutation. The rGONAD method was performed in 0.75 day pregnant WKY female rats crossed to WKY male rats. The target sequence, PAM, and ssODN at Tyr locus are shown. b Picture of the knock-in rats showing the albino with non-agouti, hooded phenotype. c Direct sequencing results of wild-type WKY (upper; WT) or the editing (below; Knock-in) rats. Red arrow indicates that one allele had the corrected sequence (T to C)

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