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Fig. 3 | BMC Biotechnology

Fig. 3

From: Donor age affects proteome composition of tenocyte-derived engineered tendon

Fig. 3

STRING interaction map of proteins differentially abundant between TEC from old (a) and young (b) tenocytes. a Two clusters of proteins are evident: ECM building collagens and intracellular structural protein involved in cytoskeleton formation. These two groups were also represented in proteins DE in older MSC constructs. Connections between the clusters signalize mechanical interaction of the cell and ECM, described by the GO annotation ‘focal adhesion’. The role of TGFBI in cell-collagen interaction is marked by multiple connections with different collagen subtypes. b Identified interactions involve integrins and respiratory chain enzyme subunits

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