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Table 5 Concordance between a software-identified top match and whether two of three clinical geneticists would definitely have considered this diagnosis based on the image alone

From: Computer face-matching technology using two-dimensional photographs accurately matches the facial gestalt of unrelated individuals with the same syndromic form of intellectual disability

Syndrome Frequency Correctly classified by neither Correctly classified by both Correctly classified by software, but not clinicians Correctly classified by clinicians, but not software McNemars Chi-square p-value Kappa
Williams 183 31 66 44 42 0.05 0.82925 0.02
Rubinstein-Taybi 155 28 61 31 35 0.24 0.62246 0.11
Floating Harbor 61 7 33 9 12 0.43 0.51269 0.16
Coffin Lowry 154 42 41 47 24 7.45 0.00634 0.10
Kabuki 195 23 88 18 66 27.43 <.00001 0.09
Smith Magenis 124 34 38 34 18 4.92 0.02650 0.17
PACS1 39 33 2 4 0 4.00 0.04550 0.46
Kleefstra 128 52 9 63 4 51.96 <.00001 0.05
Koolan-de Vries 120 30 37 29 24 0.47 0.49221 0.12
Cornelia de Lange 441 52 264 65 60 0.20 0.65472 0.26