Fig. 4

Repetitive DNA elements depleting by MRB-seq. a Read disribution of MB-seq and MRB-seq across different genomic features. b Sequencing depth of MB-seq and MRB-seq across different genomic features. MRB-seq successfully depleted repeat sequences and increased the percentage of other genomic features. c-e Scatter plots displaying the correlation of methylation levels between MB-seq and MRB-seq in transposons (c), CGIs (d) and promoters (e). It is shown that, other than in transposons, the repeats-removal process did not significantly affect the methylation level of other genomic features