Fig. 1From: Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates a Design of the HBc K1-K1 construct. Amino acid sequences of inserted lysine linkers are showed in upper part. Below, introduced unique restriction sites at both ends of the linkers (XbaI/NotI in Core1 and EcoRI/NheI in Core2) are underlined. Purified K1-K1 VLPs were characterized by Coomassie-stained PAAG (b) and electron microscopy (c)Back to article page