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Table 1 Summary of computational annotations and reported topologies of known membrane and soluble proteins

From: A split ubiquitin system to reveal topology and released peptides of membrane proteins

  WKS1 VKOR PIP1;2 HPN GPR3 GUS
Gene ID KT834954.1 NM_119742.4 NM_130159 X07732.1 NM_005281 AJ298139.1
  N C N C N C N C N C N C
TMHMM no TMHs in in in in in out out in no TMHs
SOSUI no TMHs No results No results in out No results no TMHs
TOPCONS no TMHs in out in in no TMHs out in no TMHs
PHILIUS no TMHs in out in in no TMHs in in no TMHs
HMMTOP no TMHs in out in in in out out in no TMHs
TMPRED no TMHs out in in in out out in out out in
POLYPHOBIUS no TMHs in out out in in out out in no TMHs
HMM–TM in out in out out in in out out out no TMHs
OCTOPUS no TMHs in out in in no TMHs out out no TMHs
SUT in in out out in in in out out in Soluble
Reference    out out in in in out out in Soluble
  1. N, N terminus. C, C terminus. Italic, different from experimental results. Computational predictions were done in versions of December 2016