Fig. 7
From: Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
The evaluation of the renal protective effects of PEG-FGF21 and FGF21 in db/db mice. The urinary albumin/creatinine ratios (ACR) of db/db mice were determined after treatment by PEG-FGF21 and FGF21 (a); Representative PAS staining of renal tissues of db/db mice after treatment (b); Western blot analysis of the levels of renal collagen IV, fibronectin and laminin (c); Semi-quantitative analysis of renal collagen IV (d), firbonectin (e) and laminin (f) expressions by western blot after treatment with FGF21 and PEG-FGF21