Fig. 6
From: Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
PEG-rhFGF21 ameliorates diabetes-induced renal inflammation and fibrosis. qRT-PCR analysis of the expressions of TGF-β, PAI-1 and Type IV collagen. PEG-FGF21 can significantly suppress the TGF-β, PAI-1 and Type IV collagen mRNA levels in the kidney compared with FGF21 treatment (a-c). The mRNA levels were normalized by the β-actin mRNA level. Data are means ± SEM. *P ≤ 0.05, versus DIO + FGF21 treated DIO mice. n = 10 in each group