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Fig. 5 | BMC Biotechnology

Fig. 5

From: Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice

Fig. 5

PEG-FGF21 and FGF21 administration treats established nephropathy in DIO mice of type 2 diabetes. Representative PAS staining of renal tissues of DIO mice after treatment (a); Western blot analysis of the levels of inflammatory factors (CD68, IL-6 and TNF-a) in renal tissues of DIO mice after treatment with FGF21 and PEG-FGF21 (b); Semi-quantitative analysis of CD68 (c), and IL-6(d), TNF-ɑ (e) expression in renal tissues after treatment with FGF21 and PEG-FGF21 by western blot; Semi-quantitative evaluation of renal collagen IV, laminin and firbonectin levels based on immnuohistochemical stains (f); Western blot analysis of the levels of renal collagen IV, laminin and firbonectin (g); Semi-quantitative analysis of collagen IV (h), and firbonectin (i), laminin (j) expression in renal tissues after treatment with FGF21 and PEG-FGF21 by western blot. *P ≤ 0.05 versus DIO + FGF21 treated DIO mice. n = 10 in each group

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