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Fig. 1 | BMC Biotechnology

Fig. 1

From: A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli

Fig. 1

A point mutation in rpoB conferred improved cell growth and succinic acid production to Suc-T110 under osmotic stress. a Cell growth of RpoBD645Y (A Suc-T110 derivative harboring rpoB G1960T [RpoBD654Y]), and AgaRR109W (A Suc-T110 derivative harboring agaR C325T [AgaRR109W]) along with the parental strain, Suc-T110, under normal (5% w/v glucose) or osmotic stress (12% w/v glucose) conditions. b SA production by RpoBD645Y, AgaRR109W, and Suc-T110 after 96 h of fermentation. Data are the mean with the standard error of the mean (SEM, n = 3). The significance of differences was calculated by one-way ANOVA; asterisks indicate a significant difference from the control (** P < 0.01; * P < 0.05; NS = not significant)

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