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Fig. 3 | BMC Biotechnology

Fig. 3

From: New tools to convert bacterial artificial chromosomes to a self-excising design and their application to a herpes simplex virus type 1 infectious clone

Fig. 3

Comparison of virus propagation and neurovirulence. a Single-step growth curves comparing propagation of unexcised vHSVF-BFP (P2), excised vHSVF-BFP (P4cre), and self-excised vHSVF-CREin (P2a). Virus was harvested from cell media (dashed lines) and cells (solid lines) and titers were measured by plaque assay. b Kaplan–Meier presentation of mouse survival following intracranial inoculation of unexcised vHSVF-BFP (P2), excised vHSVF-BFP (P4cre), and two isolates of self-excised vHSVF-CREin (P2a and P2c)

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BMC Biotechnology

ISSN: 1472-6750

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