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Table 2 Results of PD50 test. PD50 test was performed as described by the OIE. The bovine PD50 content of the vaccine was calculated based on the Reed-Muench method from each animal protected in each group

From: Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle

Groups

Animal No.

Antibody titer at 28 dpv

Protection

Days of onset of lesion

Rate of protection

PD50

LPBE

VN

Yes

-

5/5

 
  

LPBE

VN

Yes

-

5/5

11.75

1 dose

1558

360

64

Yes

-

1559

1440

64

Yes

-

1584

1440

724

Yes

-

1601

180

362

Yes

-

1602

720

512

Yes

-

1/3 dose

1534

1440

724

Yes

-

3/4

1548

1440

724

No

D10

1562

90

724

Deatha

-

1567

720

431

Yes

-

1576

180

76

Yes

-

1/9 dose

29

1440

724

Yes

-

4/5

77

360

54

Yes

-

1136

2880

724

Yes

-

1139

180

4

No

D6

1580

360

512

Yes

-

Control

1561

22

16

No

D5

0/2

 

1590

45

8

No

D5

  1. a One animal in this group died after challenge, but with no typical lesions of FMD