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Table 2 Results of PD50 test. PD50 test was performed as described by the OIE. The bovine PD50 content of the vaccine was calculated based on the Reed-Muench method from each animal protected in each group

From: Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle

Groups Animal No. Antibody titer at 28 dpv Protection Days of onset of lesion Rate of protection PD50
LPBE VN Yes - 5/5  
   LPBE VN Yes - 5/5 11.75
1 dose 1558 360 64 Yes -
1559 1440 64 Yes -
1584 1440 724 Yes -
1601 180 362 Yes -
1602 720 512 Yes -
1/3 dose 1534 1440 724 Yes - 3/4
1548 1440 724 No D10
1562 90 724 Deatha -
1567 720 431 Yes -
1576 180 76 Yes -
1/9 dose 29 1440 724 Yes - 4/5
77 360 54 Yes -
1136 2880 724 Yes -
1139 180 4 No D6
1580 360 512 Yes -
Control 1561 22 16 No D5 0/2  
1590 45 8 No D5
  1. a One animal in this group died after challenge, but with no typical lesions of FMD