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Table 1 Analysis of cytokine released (pg/mL) in the supernatant of co-culture of APCs and T lymphocytes from NOD and BALB/c mice stimulated with medium, Con-A, or insulin

From: New strategy for testing efficacy of immunotherapeutic compounds for diabetes in vitro

Cytokine Medium Con-A Insulin
  NOD BALB/C NOD BALB/C NOD BALB/C
IL-6 6234 ± 3217a 494 ± 377 9660 ± 2001 7632 ± 2104 13,881 ± 1138b 2762 ± 261
IFN-Υ 96 ± 8a 4.5 ± 0.1 4754 ± 1725 3253 ± 3224 480 ± 204a 13 ± 11
IL-17 368 ± 27b 23.6 ± 22 680 ± 219a 28.8 ± 20.7 984 ± 34a 53 ± 26
IL-10 89 ± 12a 1.8 ± 0.5 758 ± 137b 50 ± 35 595 ± 118b 33 ± 21
  1. Data are reported as means ± SD for 3 separate experiments
  2. a P < 0.001
  3. b P < 0.05 when compared BALB/c to NOD mice (t-test)