Table 1 The up-regulated reductases in vanillin-tolerant S. cerevisiae
Genes | Log2(FC)a | Function of genes |
|---|---|---|
ARA1 | 2.455 | NADP+ dependent arabinose dehydrogenase |
ARA2 | 2.715 | NAD-dependent arabinose dehydrogenase |
BDH1 | 2.394 | NAD-dependent (R,R)-butanediol dehydrogenase catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin |
BDH2 | 4.594 | Putative medium-chain alcohol dehydrogenase with similarity to BDH1 |
YNL134C | 2.298 | NADH-dependent aldehyde reductase involved in detoxification of furfural |
YJR096W | 2.264 | Xylose and arabinose reductase |
ALD6 | 2.875 | Cytosolic aldehyde dehydrogenase which prefers NADP+, conversion of acetaldehyde to acetate |
ZWF1 | 1.773 | Glucose-6-phosphate dehydrogenase, catalyzes the first step of the pentose phosphate pathway |
IDP3 | 2.510 | Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+) |
MDH3 | 1.198 | Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate |
ADH6b | −0.934 | NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity |