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Table 1 Comparison of major fermentation performance index with different fermentation strategies

From: Continuous enhancement of iturin A production by Bacillus subtilis with a stepwise two-stage glucose feeding strategy

Fermentation strategy Iturin A concentration at 72 h (g/L) Maximum Iturin A conc. (g/L) & time Maximum total cell number (CFU/mL) Ratio of spores to total cells after 48 h Iturin A productivity at 72 h (g/L/h)
Batch fermentation 0.57 0.57 (72 h) 1.3 × 1010 0.82–1.04 0.0079
Low feeding rate (F = 0.28 g/L/h) 0.62 0.64 (83 h) 1.7 × 1010 0.80–1.08 0.0086
Moderate feeding rate (F = 0.56 g/L/h) 0.70 0.78 (84 h) 1.4 × 1010 0.79–0.92 0.0097
High feeding rate (F = 1.12 g/L/h) 0.51 0.53 (70 h) 1.6 × 1010 0.69–1.04 0.0071
Two-stage feeding strategy (F = 0.56 → F = 0.28 g/L/h) 0.68 1.12 (110 h) 1.4 × 1010 0.80–0.86 0.0094