Fig. 3From: Active immunization with Tocilizumab mimotopes induces specific immune responsesAlignment of the insert sequences expressed by phage clones. Phe229, Tyr230, Glu278 and Phe279 from the D3 domain of site I contribute the majority to form the initial IL-6/IL-6Rα binary complex. We aligned the mimotope sequences and found that phage mimics 4A124, 4A125 and 4A126 bear these key amino acids (4A124: Phe229, Tyr230; 4A125: Glu278, Phe279; 4A126: Glu278, Phe279)Back to article page