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Fig. 2 | BMC Biotechnology

Fig. 2

From: Active immunization with Tocilizumab mimotopes induces specific immune responses

Fig. 2

Isolated phage clones can mimic the original antigen. To demonstrate mimicry between the peptides and the original antigen, three independently phage competitive binding assay were then performed. a In Set one, rIL-6R could displace a large amount of bound phage from the Tocilizumab by using titration. b In Set two, the phage binding rate of all phage mimics decreased significantly after we added rIL-6R to compete with the binding of phage particles to Tocilizumab by using ELISA. c In Set three, the phage competitive rate of all phage mimics increased significantly after we added phage particles to compete with the binding of Tocilizumab to rIL-6R using ELISA (mean ± SD, *, P < 0.05; **, P < 0.005)

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