Table 3 LD 50 , EC 50 and therapeutic index values of recombinant cIFN-α determined via an in vitro assay, by using Vero cells challenged with HSV-1
From: Auto-induction expression of human consensus interferon-alpha in Escherichia coli
Interferon | LD 50 | EC 50 | Therapeutic index (LD 50 /EC 50 ) |
|---|---|---|---|
Recombinant cIFN-α | 12.68 μg/ml | 30.85 ng/ml | 411.02 |
Commercial IFN-α2a | 992.81 IU/ml | 100.35 IU/ml | 9.89 |