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Table 3 LD 50 , EC 50 and therapeutic index values of recombinant cIFN-α determined via an in vitro assay, by using Vero cells challenged with HSV-1

From: Auto-induction expression of human consensus interferon-alpha in Escherichia coli

Interferon LD 50 EC 50 Therapeutic index (LD 50 /EC 50 )
Recombinant cIFN-α 12.68 μg/ml 30.85 ng/ml 411.02
Commercial IFN-α2a 992.81 IU/ml 100.35 IU/ml 9.89