From: Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency loss
Sample name
Volume mean diameter (nm)
Day 0
Day 7
Day 28
Average
Wild-type
38.9
39.2
39.6
39.2 ± 0.4
5Cys
36.5
36.3
38.8
37.2 ± 1.4
3Cys
35.5
33.5
35.1 ± 1.4
2Cys
52.6
49.7
49.3
50.5 ± 1.8