Figure 9From: Modifications of cysteine residues in the transmembrane and cytoplasmic domains of a recombinant hemagglutinin protein prevent cross-linked multimer formation and potency lossA and B Pre-clinical mouse immunogenicity study results. Sera samples from mice immunized with the H3 A/Texas 5Cys SDV rHA antigen (B1-B3) and with the H3 A/Texas wild-type rHA antigen (A1-A3) were tested in the HAI assay using both antigens, the H3 A/Texas 5Cys rHA antigen (Panel A, left) and the H3 A/Texas wild-type rHA antigen (Panel B, right). In each plot, the dotted line represents 4× the mean value for the day 0 titer.Back to article page