TY - JOUR AU - Gitlin, I. AU - Carbeck, J. D. AU - Whitesides, G. M. PY - 2006 DA - 2006// TI - Why are proteins charged? Networks of charge-charge interactions in proteins measured by charge ladders and capillary electrophoresis JO - Angew Chem Int Ed Engl VL - 45 UR - https://doi.org/10.1002/anie.200502530 DO - 10.1002/anie.200502530 ID - Gitlin2006 ER - TY - JOUR AU - Whitcomb, D. AU - Lowe, M. PY - 2007 DA - 2007// TI - Human pancreatic digestive enzymes JO - Dig Dis Sci VL - 52 UR - https://doi.org/10.1007/s10620-006-9589-z DO - 10.1007/s10620-006-9589-z ID - Whitcomb2007 ER - TY - JOUR AU - Kay, J. AU - Kassell, B. PY - 1971 DA - 1971// TI - The autoactivation of trypsinogen JO - J Biol Chem VL - 246 ID - Kay1971 ER - TY - JOUR AU - Sahin-Tóth, M. PY - 2006 DA - 2006// TI - Biochemical models of hereditary pancreatitis JO - Endocrinol Metab Clin North Am VL - 35 UR - https://doi.org/10.1016/j.ecl.2006.02.002 DO - 10.1016/j.ecl.2006.02.002 ID - Sahin-Tóth2006 ER - TY - JOUR AU - Teich, N. AU - Rosendahl, J. AU - Tóth, M. AU - Mössner, J. AU - Sahin-Tóth, M. PY - 2006 DA - 2006// TI - Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis JO - Hum Mutat VL - 27 UR - https://doi.org/10.1002/humu.20343 DO - 10.1002/humu.20343 ID - Teich2006 ER - TY - JOUR AU - Kiraly, O. AU - Guan, L. AU - Szepessy, E. AU - Toth, M. AU - Kukor, Z. AU - Sahin-Toth, M. PY - 2006 DA - 2006// TI - Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli JO - Protein Expres Purif VL - 48 UR - https://doi.org/10.1016/j.pep.2006.01.023 DO - 10.1016/j.pep.2006.01.023 ID - Kiraly2006 ER - TY - JOUR AU - Nemoda, Z. AU - Sahin-Tóth, M. PY - 2005 DA - 2005// TI - The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M505661200 DO - 10.1074/jbc.M505661200 ID - Nemoda2005 ER - TY - STD TI - Ózsvári B, Hegyi P, Sahin-Tóth M: The Guinea Pig Pancreas Secretes a Single Trypsinogen Isoform, Which is defective in autoactivation. Pancreas 2008, 37(2):182–188. ID - ref8 ER - TY - JOUR AU - Pasternak, A. AU - Liu, X. AU - Lin, T. AU - Hedstrom, L. PY - 1998 DA - 1998// TI - Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen† JO - Biochemistry VL - 37 UR - https://doi.org/10.1021/bi980951d DO - 10.1021/bi980951d ID - Pasternak1998 ER - TY - JOUR AU - Broderick, J. W. AU - LARGMAN, C. AU - JOHNSON, J. H. AU - GEOKAS, M. C. PY - 1978 DA - 1978// TI - Human cationic trypsinogen. Purification, characterization, and characteristics of autoactivation JO - J Biol Chem VL - 253 ID - Broderick1978 ER - TY - JOUR AU - Teich, N. AU - Le Maréchal, C. AU - Kukor, Z. AU - Caca, K. AU - Witzigmann, H. AU - Chen, J. AU - Tóth, M. AU - Mössner, J. AU - Keim, V. AU - Férec, C. AU - Sahin-Tóth, M. PY - 2004 DA - 2004// TI - Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2) JO - Hum Mutat VL - 23 UR - https://doi.org/10.1002/humu.10285 DO - 10.1002/humu.10285 ID - Teich2004 ER - TY - JOUR AU - Strickler, S. S. AU - Gribenko, A. V. AU - Gribenko, A. V. AU - Keiffer, T. R. AU - Tomlinson, J. AU - Reihle, T. AU - Loladze, V. V. AU - Makhatadze, G. I. PY - 2006 DA - 2006// TI - Protein stability and surface electrostatics: a charged relationship JO - Biochemistry VL - 45 UR - https://doi.org/10.1021/bi0600143 DO - 10.1021/bi0600143 ID - Strickler2006 ER - TY - JOUR AU - Sanchez-Ruiz, J. M. AU - Makhatadze, G. I. PY - 2001 DA - 2001// TI - To charge or not to charge? JO - Trends Biotechnol VL - 19 UR - https://doi.org/10.1016/S0167-7799(00)01548-1 DO - 10.1016/S0167-7799(00)01548-1 ID - Sanchez-Ruiz2001 ER - TY - JOUR AU - Miklos, A. E. AU - Kluwe, C. AU - Der, B. S. AU - Pai, S. AU - Sircar, A. AU - Hughes, R. A. AU - Berrondo, M. AU - Xu, J. AU - Codrea, V. AU - Buckley, P. E. AU - Calm, A. M. AU - Welsh, H. S. AU - Warner, C. R. AU - Zacharko, M. A. AU - Carney, J. P. AU - Gray, J. J. AU - Georgiou, G. AU - Kuhlman, B. AU - Ellington, A. D. PY - 2012 DA - 2012// TI - Structure-based design of supercharged, highly thermoresistant antibodies JO - Chem Biol VL - 19 UR - https://doi.org/10.1016/j.chembiol.2012.01.018 DO - 10.1016/j.chembiol.2012.01.018 ID - Miklos2012 ER - TY - JOUR AU - Lawrence, M. S. AU - Phillips, K. J. AU - Liu, D. R. PY - 2007 DA - 2007// TI - Supercharging proteins can impart unusual resilience JO - J Am Chem Soc VL - 129 UR - https://doi.org/10.1021/ja071641y DO - 10.1021/ja071641y ID - Lawrence2007 ER - TY - JOUR AU - McNaughton, B. R. AU - Cronican, J. J. AU - Thompson, D. B. AU - Liu, D. R. PY - 2009 DA - 2009// TI - Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0807883106 DO - 10.1073/pnas.0807883106 ID - McNaughton2009 ER - TY - JOUR AU - Simeonov, P. AU - Berger-Hoffmann, R. AU - Hoffmann, R. AU - Sträter, N. AU - Zuchner, T. PY - 2011 DA - 2011// TI - Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield JO - Protein Eng Des Sel VL - 24 UR - https://doi.org/10.1093/protein/gzq104 DO - 10.1093/protein/gzq104 ID - Simeonov2011 ER - TY - JOUR AU - Gaboriaud, C. AU - Serre, L. AU - Guy-Crotte, O. AU - Forest, E. AU - Fontecilla-Camps, J. C. PY - 1996 DA - 1996// TI - Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151 JO - J Mol Biol VL - 259 UR - https://doi.org/10.1006/jmbi.1996.0376 DO - 10.1006/jmbi.1996.0376 ID - Gaboriaud1996 ER - TY - JOUR AU - Sahin-Tóth, M. AU - Kukor, Z. AU - Nemoda, Z. PY - 2006 DA - 2006// TI - Human cationic trypsinogen is sulfated on Tyr154 JO - FEBS J VL - 273 UR - https://doi.org/10.1111/j.1742-4658.2006.05501.x DO - 10.1111/j.1742-4658.2006.05501.x ID - Sahin-Tóth2006 ER - TY - JOUR AU - Sahin-Toth, M. AU - Gráf, L. AU - Tóth, M. PY - 1999 DA - 1999// TI - Trypsinogen stabilization by mutation Arg117 → His: a unifying pathomechanism for hereditary pancreatitis? JO - Biochem Biophys Res Commun VL - 264 UR - https://doi.org/10.1006/bbrc.1999.1565 DO - 10.1006/bbrc.1999.1565 ID - Sahin-Toth1999 ER - TY - JOUR AU - Kukor, Z. AU - Toth, M. AU - Pal, G. AU - Sahin-Toth, M. PY - 2002 DA - 2002// TI - Human cationic trypsinogen - Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M110959200 DO - 10.1074/jbc.M110959200 ID - Kukor2002 ER - TY - JOUR AU - Bustin, M. AU - Conway-Jacobs, A. PY - 1971 DA - 1971// TI - Intramolecular activation of porcine pepsinogen JO - J Biol Chem VL - 246 ID - Bustin1971 ER - TY - JOUR AU - al-Janabi, J. AU - Hartsuck, J. A. AU - Tang, J. PY - 1972 DA - 1972// TI - Kinetics and mechanism of pepsinogen activation JO - J Biol Chem VL - 247 ID - al-Janabi1972 ER - TY - JOUR AU - Barranco-Medina, S. AU - Pozzi, N. AU - Vogt, A. D. AU - Di Cera, E. PY - 2013 DA - 2013// TI - Histone H4 promotes prothrombin autoactivation JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.509786 DO - 10.1074/jbc.M113.509786 ID - Barranco-Medina2013 ER - TY - JOUR AU - Várallyay, É. AU - Pál, G. AU - Patthy, A. AU - Szilágyi, L. AU - Gráf, L. PY - 1998 DA - 1998// TI - Two mutations in Rat trypsin confer resistance against autolysis JO - Biochem Biophys Res Commun VL - 243 UR - https://doi.org/10.1006/bbrc.1997.8058 DO - 10.1006/bbrc.1997.8058 ID - Várallyay1998 ER - TY - JOUR AU - Sahin-Toth, M. AU - Toth, M. PY - 2000 DA - 2000// TI - Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen JO - Biochem Bioph Res Co VL - 278 UR - https://doi.org/10.1006/bbrc.2000.3797 DO - 10.1006/bbrc.2000.3797 ID - Sahin-Toth2000 ER - TY - JOUR AU - Sahin-Toth, M. PY - 2001 DA - 2001// TI - The pathobiochemistry of hereditary pancreatitis: studies on recombinant human cationic trypsinogen JO - Pancreatology VL - 1 UR - https://doi.org/10.1159/000055848 DO - 10.1159/000055848 ID - Sahin-Toth2001 ER - TY - JOUR AU - Simon, P. AU - Weiss, F. U. AU - Sahin-Toth, M. AU - Parry, M. AU - Nayler, O. AU - Lenfers, B. AU - Schnekenburger, J. AU - Mayerle, J. AU - Domschke, W. AU - Lerch, M. M. PY - 2002 DA - 2002// TI - Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 - Cys) that alters autoactivation and autodegradation of cationic trypsinogen JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M108073200 DO - 10.1074/jbc.M108073200 ID - Simon2002 ER - TY - JOUR AU - Pál, G. AU - Sprengel, G. AU - Patthy, A. AU - Gráf, L. PY - 1994 DA - 1994// TI - Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis JO - FEBS Lett VL - 342 UR - https://doi.org/10.1016/0014-5793(94)80584-9 DO - 10.1016/0014-5793(94)80584-9 ID - Pál1994 ER - TY - JOUR AU - Pál, G. AU - Szilágyi, L. AU - Gráf, L. PY - 1996 DA - 1996// TI - Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis JO - FEBS Lett VL - 385 UR - https://doi.org/10.1016/0014-5793(96)00376-6 DO - 10.1016/0014-5793(96)00376-6 ID - Pál1996 ER - TY - JOUR AU - Sahin-Toth, M. PY - 2000 DA - 2000// TI - Human cationic trypsinogen - Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.M002943200 DO - 10.1074/jbc.M002943200 ID - Sahin-Toth2000 ER - TY - JOUR AU - Shevchenko, A. AU - Wilm, M. AU - Vorm, O. AU - Mann, M. PY - 1996 DA - 1996// TI - Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels JO - Anal Chem VL - 68 UR - https://doi.org/10.1021/ac950914h DO - 10.1021/ac950914h ID - Shevchenko1996 ER - TY - JOUR AU - Eswar, N. AU - Webb, B. AU - Marti-Renom, M. A. AU - Madhusudhan, M. S. AU - Eramian, D. AU - Shen, M. AU - Pieper, U. AU - Sali, A. PY - 2006 DA - 2006// TI - Comparative protein structure modeling using Modeller JO - Curr Protoc Bioinformatics VL - 5 ID - Eswar2006 ER - TY - JOUR AU - Shen, M. AU - Sali, A. PY - 2006 DA - 2006// TI - Statistical potential for assessment and prediction of protein structures JO - Protein Sci VL - 15 UR - https://doi.org/10.1110/ps.062416606 DO - 10.1110/ps.062416606 ID - Shen2006 ER - TY - JOUR AU - Zhang, J. AU - Liang, Y. AU - Zhang, Y. PY - 2011 DA - 2011// TI - Atomic-level protein structure refinement using fragment-guided molecular dynamics conformation sampling JO - Structure VL - 19 UR - https://doi.org/10.1016/j.str.2011.09.022 DO - 10.1016/j.str.2011.09.022 ID - Zhang2011 ER - TY - JOUR AU - Emsley, P. AU - Lohkamp, B. AU - Scott, W. G. AU - Cowtan, K. PY - 2010 DA - 2010// TI - Features and development of Coot JO - Acta Crystallogr D Biol Crystallogr VL - 66 UR - https://doi.org/10.1107/S0907444910007493 DO - 10.1107/S0907444910007493 ID - Emsley2010 ER - TY - BOOK AU - Schrödinger, L. L. PY - 2010 DA - 2010// TI - The PyMOL Molecular Graphics System, Version 1.3r1 ID - Schrödinger2010 ER - TY - JOUR AU - Dolinsky, T. J. AU - Czodrowski, P. AU - Li, H. AU - Nielsen, J. E. AU - Jensen, J. H. AU - Klebe, G. AU - Baker, N. A. PY - 2007 DA - 2007// TI - PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations JO - Nucleic Acids Res VL - 35 UR - https://doi.org/10.1093/nar/gkm276 DO - 10.1093/nar/gkm276 ID - Dolinsky2007 ER - TY - JOUR AU - Dolinsky, T. J. AU - Nielsen, J. E. AU - McCammon, J. A. AU - Baker, N. A. PY - 2004 DA - 2004// TI - PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations JO - Nucleic Acids Res VL - 32 UR - https://doi.org/10.1093/nar/gkh381 DO - 10.1093/nar/gkh381 ID - Dolinsky2004 ER -